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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 145 - 151 (7page)
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초록· 키워드
오류제보하기
Periodontitis is an inflammatory disorder of the periodontium and is characterized by destruction of the tooth supporting tissues, mediated by the upregulation of synthesis and release of a variety of pro-inflammatory factors. Inflammatory cytokines and prostaglandins upregulate RANKL and its subsequent binding to RANK stimulates osteoclast formation, resorption activity, and survival. In our present study, we investigated the effects of HP08-0111, composed of Coptis japonica (Thunb.) Makino, vitamin C and vitamin E,upon inflammatory responses, osteoclastogenesis and alveolar bone loss. HP08-0111 decreased the expression of IL-1βand COX2 on LPS-induced RAW 264.7 cells and inhibited osteoclast-specific genes such as c-Fos, MMP-9, and TRAP.
HP08-0111 also exhibited protective effects against alveolar bone loss in rats with ligature-induced periodontitis. Our results suggest that HP08-0111 is potentially an important therapeutic tool for the treatment of disorders associated with bone loss such as periodontitis.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Chen YJ / 2005 / Involvement of protein kinase C in the inhibition of lipopolysaccharide-induced nitric oxide production by thapsigargin in RAW 264.7 macrophages / Int J Bioc
Halliwell B / 1984 / Oxygen toxicity, oxygen radicals,transition metals and disease / Biochem J 219 (1) : 1 ~ 14
Han KY / 2007 / Inhibition of osteoclast differentiation and bone resorption by sauchinone / Biochem Pharmacol 74 (6) : 911 ~ 923
Hewett JA / 1993 / Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides / Pharmacol Rev 45 (4) : 382 ~ 411
Kim JY / 2004 / Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages / FEBS Lett 569 (1) : 321 ~ 326
Halliwell B / 1984 / Oxygen toxicity, oxygen radicals,transition metals and disease / Biochem J 219 (1) : 1 ~ 14
Han KY / 2007 / Inhibition of osteoclast differentiation and bone resorption by sauchinone / Biochem Pharmacol 74 (6) : 911 ~ 923
Hewett JA / 1993 / Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides / Pharmacol Rev 45 (4) : 382 ~ 411
Kim JY / 2004 / Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages / FEBS Lett 569 (1) : 321 ~ 326
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