지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 187 - 194 (8page)
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초록· 키워드
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Periodontitis is an inflammatory disorder of the periodontium, characterized by destruction of the tooth supporting tissues including alveolar bone and mediated by various pro-inflammatory mediators. Here, we demonstrated that HP08-0106, composed of four crude drugs-Gardenia jasminoides Grandiflora, Angelica gigas Nakai, Rehmannia glutinosa, and Schizonepeta tenuifolia in a weight ratio of 2:2:1:2, perturbs inflammatory responses, osteoclast formation in LPS-induced RAW 264.7 cells and alveolar bone resorption in ligature-induced periodontitis. HP08-0106decreased the protein level of iNOS and COX2 as well as the secreted level of IL-1β, indicating that HP08-0106 has antiinflammatory effects. HP08-0106 also inhibited the expression of genes associated with osteoclastogenesis including c-Fos, MMP-9 and TRAP. Moreover, HP08-0106exhibited a protective effect from alveolar bone loss in ligature-induced periodontitis animal models. Our results strongly suggest that HP08-0106 represent an important therapeutic tool to treat inflammatory disorders associated with bone loss such as periodontitis.
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참고문헌 (28)
참고문헌 신청
Soh Y / 2003 / Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline / Mutat Res 544(2):129~142
Underwood JR / 2009 / Stimulation of tetanus toxoid-specific immune responses by a traditional Chinese herbal medicine / Vaccine 27(47):6634~6641
Wittrant Y / 2004 / Relevance of an in vitro osteoclastogenesis system to study receptor activator of NF-kB ligand and osteoprotegerin biological activities / Exp Cell Res 293(2):292~301
Xu GL / 2009 / Preventive effect of crocin in inflamed animals and in LPS-challenged RAW 264.7 cells / J Agric Food Chem 57(18):8325~8330
Zhao Y / 2006 / Extraction and salting-out purification of alpha-galactosidase and beta-glucosidase from fresh roots of Rehmannia glutinosa / Zhong Yao Cai 29(2):137~139
Underwood JR / 2009 / Stimulation of tetanus toxoid-specific immune responses by a traditional Chinese herbal medicine / Vaccine 27(47):6634~6641
Wittrant Y / 2004 / Relevance of an in vitro osteoclastogenesis system to study receptor activator of NF-kB ligand and osteoprotegerin biological activities / Exp Cell Res 293(2):292~301
Xu GL / 2009 / Preventive effect of crocin in inflamed animals and in LPS-challenged RAW 264.7 cells / J Agric Food Chem 57(18):8325~8330
Zhao Y / 2006 / Extraction and salting-out purification of alpha-galactosidase and beta-glucosidase from fresh roots of Rehmannia glutinosa / Zhong Yao Cai 29(2):137~139
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