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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한감염학회 Infection and Chemotherapy Infection and Chemotherapy 제40권 제5호
발행연도
2008.1
수록면
259 - 265 (7page)

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Background : Doxycycline has been the drug of choice for the treatment of scrub typhus. However, scrub typhus with poor response to doxycycline was first reported in Thailand in 1996. To date, it is not known whether doxycycline resistant scrub typhus is present in Korea. To investigate the doxycycline resistance of scrub typhus in Korea, we performed an experiment to evaluate the degree of growth inhibition of Orientia tsutsugamushi at the minimal inhibitory concentration (MIC) of doxycycline. Materials and Methods : 37 isolates of Orientia tsutsugamushi were collected from Korean patients with scrub typhus during 10 year period (from 1997 to 2007). 34 isolates consisted of Boryong serotype or related serotypes. These strains were stained with FS15, a monoclonal antibody against the linear epitope on the protein located at the outer membrane of O. tsutsugamushi. Three isolates were confirmed as serotype Gilliam, which was stained by anti-Gilliam antibody. The antibody- stainable 35 isolates were incubated in media containing 0.1 and 0.2 µg/mL of doxycycline for 3 days. Then the growth indices of Orientia were measured by flow cytometry. If the growth index was greater than 10%, the isolate was tentatively classified as an isolate resistant to doxycycline and its MIC was measured. Results : Demographic and treatment data were similar to the results of previous reports. Infection was mainly observed in Inchon and the Chungcheongnam province. No patient showed delayed response to antibiotics. Of 35 hospitalized patients, 4 (11.4%) were managed at the intensive care unit, and 1 (2.9%) died of nosocomial pneumonia. All the 2 patients whose isolates were serotype Gilliam Yonchon/Ikeda-like strain were managed at the intensive care unit. Six of the 34 isolates from Korean patients exhibited growth indices greater than 10% at the MIC of doxycycline; however, the MICs of these isolates did not exceed 0.2 µg/mL. One isolate of serotype Gilliam showed an MIC of 0.0125 ug/mL, which seemed to be underestimated due to weak fluorescence of the anti-Gilliam antibody. Conclusions : Although the number of tested isolates is small, insensitivity of scrub typhus to doxycycline is not a major reason for treatment failure in Korea. Serotype Gilliam, especially Yochon/ Ikeda-like strain, may be associated with severe form of scrub typhus. More studies concerning the antibiotic susceptibility for serotype Gilliam are warranted.
#Orientia tsutsugamushi #Scrub typhus #Doxycycline #Resistance

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참고문헌 (18)

참고문헌 신청
Brown GW / 1978 / Single dose doxycycline therapy for scrub typhus / Trans R Soc Trop Med Hyg 72 : 412 ~ 416 google schola Chanta C / 2007 / Hepatic dysfunction in pediatric scrub typhus: role of liver function test in diagnosis and marker of disease severity / J Med Assoc Thai 90 : 2366 ~ 2369 google schola Hald T / 2007 / The attribution of human infections with antimicrobial resistant Salmonella bacteria in Denmark to sources of animal origin / Foodborne Pathog Dis 4 : 313 ~ google schola Kang JS / 1999 / Antigenic relationship among the eight prototype and new serotype strains of Orientia tsutsugamushi revealed by monoclonal antibodies / Microbiol Immunol 43 google schola Kantipong P / 1996 / Infection with human immunodeficiency virus does not influence the clinical severity of scrub typhus / Clin Infect Dis 23 : 1168 ~ 1170 google schola

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