지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 624 - 629 (6page)
이용수
초록· 키워드
오류제보하기
Purpose: Previous studies and our own clinical experience suggest that concurrent corticosteroid treatment for severe rickettsial disease with multiorgan failure may improve the clinical course or reduce mortality. However, the use of corticosteroids as adjunctive treatment for rickettsial diseases is controversial. We attempted to determine the influences of corticosteroid on the growth of Orientia tsutsugamushi in vitro to justify and evaluate the clinical applicability of corticosteroid in rickettsial disease. Materials and Methods: L929 cells were infected with Orientia tsutsugamushi Gilliam. Dexamethasone was added to the cells at final concentrations of 10^1 and 10^7 pg/mL. Cultures were incubated at 35°C and processed for flow cytometry on the 6th day after addition of dexamethasone. Results: Observation on the 6th day after treatment with dexamethasone in infected cultures revealed that there was no difference in fluorescence intensity among the treatment wells. Treatment of the cells with dexamethasone at concentrations of 10^1 and 10^7 pg/mL showed no influence on the growth of Orientia tsutsugamushi. Conclusion:Our results to show that isolated corticosteroid does not enhance the replication of Orientia tsutsugamushi in vitro. Concurrent use of anti-inflammatory or immunosuppressive doses of corticosteroids in conjunction with antibiotics may not have detrimental effects on the course of scrub typhus.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Annane D / 2002 / Resurrection of steroids for sepsis resuscitation / Minerva Anestesiol 68 : 127 ~ 131
Breitschwerdt EB / 1997 / Prednisolone at anti-inflammatory or immunosuppressive dosages in conjunction with doxycycline does not potentiate the severity of Rickettsia ricket
Briegel J / 1999 / Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study / Crit Care Med 27 : 723 ~
Brown GW / 1988 / Scrub typhus; pathogenesis and clinical syndrome in Biology of rickettsial disease. Vol 1. / CRC Press : 93 ~ 100
Chang WH / 1988 / Occurence of tsutsugamushi disease and prototypes of Rickettsia tsutsugamushi in Korea / J Korean Med Assoc 31 : 601 ~ 607
Breitschwerdt EB / 1997 / Prednisolone at anti-inflammatory or immunosuppressive dosages in conjunction with doxycycline does not potentiate the severity of Rickettsia ricket
Briegel J / 1999 / Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study / Crit Care Med 27 : 723 ~
Brown GW / 1988 / Scrub typhus; pathogenesis and clinical syndrome in Biology of rickettsial disease. Vol 1. / CRC Press : 93 ~ 100
Chang WH / 1988 / Occurence of tsutsugamushi disease and prototypes of Rickettsia tsutsugamushi in Korea / J Korean Med Assoc 31 : 601 ~ 607
이 논문의 저자 정보
최근 본 자료
댓글(0)
0