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논문 기본 정보

자료유형
학술저널
저자정보
Su Yeon Lee (Seoul National Univ. of Science and Technology) Sumi Bang (Seoul National Univ. of Science and Tech) Sumi Kim (Seoul National Univ. of Science and Technology) Seong Yeon Jo (Seoul National Univ. of Science and Technology) Bumchul Kim (Seoul National University of Science and Technology) Yunjae Hwang (Seoul National Univ. of Science and Technology) 노인섭 (서울과학기술대학교)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제19권 제2호
발행연도
2015.6
수록면
106 - 116 (11page)
DOI
10.1186/s40824-015-0033-3

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Background: Cellulose and its derivatives such as carboxymethyl cellulose (CMC) have been employed as a biomaterial for their diverse applications such as tissue engineering, drug delivery and other medical materials. Porosity of the scaffolds has advantages in their applications to tissue engineering such as more cell adhesion and migration leading to better tissue regeneration. After synthesis of CMC-poly(ethylene oxide) (PEO) hydrogel by mixing the solutions of both CMC-acrylate and PEO-hexa-thiols, fabrication and evaluation of a CMC-PEO gel and its film in porous form have been made for its possible applications to tissue regeneration. Physicochemical and biological properties of both CMC-PEO hydrogel and porous films have been evaluated by using physicochemical assays by SEM, FTIR and swelling behaviors as well as in vitro assays of MTT, Neutral red, BrdU, gel covering and tissue ingrowth into the pores of the CMC-PEO gel films. Degradation of CMC-PEO hydrogel was also evaluated by treating with esterase over time. Results: Chemical grafting of acrylate to CMC was verified by analyses of both FTIR and NMR. CMC-PEO hydrogel was obtained by mixing two precursor polymer solutions of CMC-acrylate and PEO-hexa-thiols and by transforming into a porous CMC-PEO gel film by gas forming of ammonium bicarbonate particles. The fabricated hydrogel has swollen in buffer to more than 6 times and degraded by esterase. The results of in vitro assays of live and dead, MTT, BrdU, Neutral red and gel covering on the cells showed excellent cell compatibility of CMC-PEO hydrogel and porous gel films. Furthermore the porous films showed excellent in vitro adhesion and migration of cells into their pore channels as observed by H&E and MT stains. Conclusions: Both CMC-PEO hydrogel and porous gel films showed excellent biocompatibility and were expected to be a good candidate scaffold for tissue engineering.
#Carboxymethyl cellulose #Poly(ethylene oxide) #Gel film #Biocompatibility #Pores

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참고문헌 (32)

참고문헌 신청
Ramli NA. / 2011 / Sodium carboxymethyl cellulose scaffolds and their physicochemical effects on partial thickness wound healing / Intl J Pharm. 403(1?2):73~82 google schola Dinarvand R. / 2006 / Thermoresponsive drug delivery using liquid crystal-embedded cellulose nitrate membranes / Drug Deliv 13(5):345~350 google schola Nouran El Badawi NE. / 2014 / Novel carbon nanotube–cellulose acetate nanocomposite membranes for water filtration applications / Desalination 344:79~85 google schola Kang H. / 2013 / Cellulose derivatives and graft copolymers as blocks for functional materials / Polym Intl 62(3):338~344 google schola Vlierberghe SV. / 2011 / Biopolymer-based hydrogels as scaffolds for tissue engineering applications : a review / Biomacromolecules 12:1387~1408 google schola

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