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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 76 - 81 (6page)
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초록· 키워드
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Potentilla supina (Rosaceae) has traditionally been used to treat disorders of hemostasis, dysentery, malaria, bloody discharge and arthritis, and it has antinociceptive and anti-inflammatory properties. However, validity of the antiinflammatory activity has not been scientifically investigated so far. Therefore, the aim of this study was to investigate the anti-inflammatory potential of P. supina using the ethanolic extract of P. supina and its sub-fractions. To evaluate the anti-inflammatory effects of P. supina, we examined the inflammatory mediators such as nitric oxide (NO), inducible nitric oxide synthase (iNOS) and prostaglandin E2 (PGE2) in RAW 264.7 cells. Our results indicated that ethyl acetate fraction significantly inhibited LPS-induced NO, iNOS and PGE2 production in RAW 264.7 cells. This result showed that ethyl acetate fraction of P. supina is expected to be a good candidate for development into a source of anti-inflammatory agents.
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참고문헌 (26)
참고문헌 신청
Dong-Bum Shin / 2006 / Antioxidative Properties and Flavonoids Contents of Matured Citrus Peel Extracts / Food Science and Biotechnology 15 (3) : 357 ~ 362
Feldmann M / 1996 / Role of cytokines in Rheumatoid arthritis / Annu Rev Immunol 14 : 397 ~ 440
Hilliquin P / 1997 / Nitric oxide as S-nitrosoproteins in Rheumatoidarthritis / Arthritis Rheum 40 : 1512 ~ 1517
Iontcheva I / 2004 / Role for moesin in lipopolysaccharide stimulated signal transduction / Infect Immun 72 : 2312 ~ 2320
Kang YH / 1996 / The nitrite scavenging and electron donating abillty of phenolic compounds / Korea J Food Sci Technol 28 : 232 ~ 239
Feldmann M / 1996 / Role of cytokines in Rheumatoid arthritis / Annu Rev Immunol 14 : 397 ~ 440
Hilliquin P / 1997 / Nitric oxide as S-nitrosoproteins in Rheumatoidarthritis / Arthritis Rheum 40 : 1512 ~ 1517
Iontcheva I / 2004 / Role for moesin in lipopolysaccharide stimulated signal transduction / Infect Immun 72 : 2312 ~ 2320
Kang YH / 1996 / The nitrite scavenging and electron donating abillty of phenolic compounds / Korea J Food Sci Technol 28 : 232 ~ 239
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