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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 209 - 216 (8page)
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초록· 키워드
오류제보하기
Stress is now recognized as a universal premorbid factor associated with many risk factors of various chronic diseases.
Acute stress may induce an individual’s adaptive response to environmental demands. However, chronic, excessive stress causes cumulative negative impacts on health outcomes through “allostatic load”. Thus, monitoring the quantified levels of long-term stress mediators would provide a timely opportunity for prevention or earlier intervention of stressrelated chronic illnesses. Although either acute or chronic stress could be quantified through measurement of changes in physiological parameters such as heart rate, blood pressure, and levels of various metabolic hormones, it is still elusive to interpret whether the changes in circulating levels of stress mediators such as cortisol can reflect the acute, chronic, or diurnal variations. Both serum and salivary cortisol levels reveal acute changes at a single point in time, but the overall long-term systemic cortisol exposure is difficult to evaluate due to circadian variations and its protein-binding capacity. Scalp hair has a fairy predictable growth rate of approximately 1 cm/month, and the most 1 cm segment approximates the last month’s cortisol production as the mean value. The analysis of cortisol in hair is a highly promising technique for the retrospective assessment of chronic stress.
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등록된 정보가 없습니다.
참고문헌 (59)
참고문헌 신청
Stalder T / 2013 / Cortisol in hair and the metabolic syndrome / J Clin Endocrinol Metab 98:2573~2580
Steudte S / 2013 / Hair cortisol as a biomarker of traumatization in healthy individuals and posttraumatic stress disorder patients / Biol Psychiatry 74:639~646
Vining RF / 1983 / Hormones in saliva: mode of entry and consequent implications for clinical interpretation / Clin Chem 29:1752~1756
Cho HJ / 2009 / Quantitative metabolic profiling of 21 endogenous corticosteroids in urine by liquid chromatography-triple quadrupole-mass spectrometry / Anal Chim Acta 632:101~108
Moon JY / 2009 / Heat-map visualization of gas chromatographymass spectrometry based quantitative signatures on steroid metabolism / J Am Soc Mass Spectrom 20:1626~1637
Steudte S / 2013 / Hair cortisol as a biomarker of traumatization in healthy individuals and posttraumatic stress disorder patients / Biol Psychiatry 74:639~646
Vining RF / 1983 / Hormones in saliva: mode of entry and consequent implications for clinical interpretation / Clin Chem 29:1752~1756
Cho HJ / 2009 / Quantitative metabolic profiling of 21 endogenous corticosteroids in urine by liquid chromatography-triple quadrupole-mass spectrometry / Anal Chim Acta 632:101~108
Moon JY / 2009 / Heat-map visualization of gas chromatographymass spectrometry based quantitative signatures on steroid metabolism / J Am Soc Mass Spectrom 20:1626~1637
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