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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 216 - 221 (6page)
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초록· 키워드
오류제보하기
Cortisol is the primary hormone responsible for the undesirable effects of stress. This study aimed to understand how electrical stimulation influences cortisol secretion, which can be advantageous for designing future implantable electrical devices, to monitor and control the cortisol level. Acutely prepared adrenal gland slices of Sprague-Dawley rats were electrically stimulated at various frequencies, in the presence and absence of adrenocorticotropic hormone (ACTH) and the resultant cortisol levels determined. Electrical stimulation at ≥5 Hz frequency inhibited ACTH-induced cortisol secretion, but electrical stimulation alone did not have any effect. Furthermore, when applied in the presence of TTA-P2, a T-type Ca2+ channel inhibitor, electrical stimulation presented no influence on ACTH-induced cortisol secretion. Our results suggest that the inhibition of the T-type Ca2+ channels by electrical stimulation may contribute to its suppression of cortisol secretion.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Kozlov, A.I. / 2014 / Cortisol as a marker of stress / Human Physiology 40:224~236
Bozovic, D. / 2013 / Salivary cortisol levels as a biological marker of stress reaction / Med. Arch. 67:374~377
Christiansen, J.J. / 2007 / Effects of cortisol on carbohydrate, lipid, and protein metabolism: studies of acute cortisol withdrawal in adrenocortical failure / J. Clin. Endocrinol. Metab. 92:3553~3559
De Feo, P. et al / 1989 / Contribution of cortisol to glucose counterregulation in humans / Am. J. Physiol.-Endocrinol. Metab. 257:E35~E42
Dinneen, S. / 1993 / Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans / J. Clin. Invest. 92:2283~2290
Bozovic, D. / 2013 / Salivary cortisol levels as a biological marker of stress reaction / Med. Arch. 67:374~377
Christiansen, J.J. / 2007 / Effects of cortisol on carbohydrate, lipid, and protein metabolism: studies of acute cortisol withdrawal in adrenocortical failure / J. Clin. Endocrinol. Metab. 92:3553~3559
De Feo, P. et al / 1989 / Contribution of cortisol to glucose counterregulation in humans / Am. J. Physiol.-Endocrinol. Metab. 257:E35~E42
Dinneen, S. / 1993 / Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans / J. Clin. Invest. 92:2283~2290
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