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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 265 - 273 (9page)
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Tau protein is encoded in the microtubule-associated protein tau (MAPT) gene and contributes to the stability of microtubules in axons. Despite of its basic isoelectric point and high solubility, tau is often found in intraneuronal filamentous inclusions such as paired helical filaments (PHFs), which are the primary constituent of neurofibrillary tangles (NFTs). This pathological feature is the nosological entity termed "tauopathies" which notably include Alzheimer's disease (AD). A proteinaceous signature of all tauopathies is hyperphosphorylation of the accumulated tau, which has been extensively studied as a major pharmacological target for AD therapy. However, in addition to phosphorylation events, tau undergoes a number of diverse posttranslational modifications (PTMs) which appear to be controlled by complex crosstalk. It remains to be elucidated which of the PTMs or their combinations have pro-aggregation or anti-aggregation properties. In this review, we outline the consequences of and communications between several key PTMs of tau, such as acetylation, phosphorylation, and ubiquitination, focusing on their roles in aggregation and degradation. We place emphasis on the structure of tau protofilaments from the human AD brain, which may be good targets to modulate etiological PTMs which cause tau aggregation.
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참고문헌 (93)
참고문헌 신청
Mandelkow EM / 1998 / Tau in Alzheimer's disease / Trends Cell Biol 8:425~427
Andreadis A / 2006 / Misregulation of tau alternative splicing in neurodegeneration and dementia / Prog Mol Subcell Biol 44:89~107
Goedert M / 1989 / Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease / Neuron 3:519~526
Goedert M / 1992 / p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected] / FEBS Lett 312:95~99
Kyte J / 1982 / A simple method for displaying the hydropathic character of a protein / J Mol Biol 157:105~132
Andreadis A / 2006 / Misregulation of tau alternative splicing in neurodegeneration and dementia / Prog Mol Subcell Biol 44:89~107
Goedert M / 1989 / Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease / Neuron 3:519~526
Goedert M / 1992 / p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected] / FEBS Lett 312:95~99
Kyte J / 1982 / A simple method for displaying the hydropathic character of a protein / J Mol Biol 157:105~132
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