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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 263 - 268 (6page)
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β-Agarase cleaves the β-1,4 linkages of agar to produce neoagarooligosaccharides (NAO), which are associated with various physiological functions. However, the immunological functions of NAO are still unclear. In this study, we demonstrated that β-agarase DagA-produced neoagarohexaose (DP6), an NAO product, promoted the maturation of dendritic cells (DCs) by Toll-like receptor 4 (TLR4). DP6 directly and indirectly enhanced the activation of natural killer (NK) cells in a TLR4-dependent manner in vitro and in vivo. Finally, the antitumor activity of DP6 against B16F1 melanoma cells was inhibited in NK cell-depletion systems by using NK-cell depleting antibodies in vivo. Collectively, the results indicated that DP6 augments antitumor immunity against B16F1 melanoma cells via the activation of DC-mediated NK cells in a TLR4-dependent manner. Thus, DP6 is a potential candidate adjuvant that acts as an immune cell modulator for the treatment of melanoma.
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참고문헌 (18)
참고문헌 신청
Aleem E / 2013 / beta-Glucans and their applications in cancer therapy: focus on human studies / Anticancer Agents Med Chem 13 : 709 ~ 719
Cheng WF / 2003 / CD8＋ T cells, NK cells and IFN-gamma are important for control of tumor with downregulated MHC class I expression by DNA vaccination / Gene Ther 10 : 1311
Cillo C / 1987 / Generation of drug-resistant variants in metastatic B16 mouse melanoma cell lines / Cancer Res 47 : 2604 ~ 2608
Enoki T / 2010 / Oligosaccharides from agar inhibit pro-inflammatory mediator release by inducing heme oxygenase 1 / Biosci Biotechnol Biochem 74 : 766 ~ 770
Fu XT / 2010 / Agarase: review of major sources, categories, purification method, enzyme characteristics and applications / Mar Drugs 8 : 200 ~ 218
Cheng WF / 2003 / CD8＋ T cells, NK cells and IFN-gamma are important for control of tumor with downregulated MHC class I expression by DNA vaccination / Gene Ther 10 : 1311
Cillo C / 1987 / Generation of drug-resistant variants in metastatic B16 mouse melanoma cell lines / Cancer Res 47 : 2604 ~ 2608
Enoki T / 2010 / Oligosaccharides from agar inhibit pro-inflammatory mediator release by inducing heme oxygenase 1 / Biosci Biotechnol Biochem 74 : 766 ~ 770
Fu XT / 2010 / Agarase: review of major sources, categories, purification method, enzyme characteristics and applications / Mar Drugs 8 : 200 ~ 218
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