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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 237 - 246 (10page)
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초록· 키워드
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Synapse is the basic structural and functional component for neural communication in the brain. The presynaptic terminal is the structural and functionally essential area that initiates communication and maintains the continuous functional neural information flow. It contains synaptic vesicles (SV) filled with neurotransmitters, an active zone for release, and numerous proteins for SV fusion and retrieval. The structural and functional synaptic plasticity is a representative characteristic; however, it is highly vulnerable to various pathological conditions. In fact, synaptic alteration is thought to be central to neural disease processes. In particular, the alteration of the structural and functional phenotype of the presynaptic terminal is a highly significant evidence for neural diseases. In this review, we specifically describe structural and functional alteration of nerve terminals in several neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD).
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Abramov E / 2009 / Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses / Nat Neurosci 12 : 1567 ~ 1576
Cirrito JR / 2005 / Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo / Neuron 48 : 913 ~ 922
Cirrito JR / 2008 / Endocytosis is required for synaptic activity-dependent release of amyloidbeta in vivo / Neuron 58 : 42 ~ 51
Del Prete D / 2014 / APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that
Fogel H / 2014 / APP homodimers transduce an amyloid-beta-mediated increase in release probability at excitatory synapses / Cell Rep 7 : 1560 ~ 1576
Cirrito JR / 2005 / Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo / Neuron 48 : 913 ~ 922
Cirrito JR / 2008 / Endocytosis is required for synaptic activity-dependent release of amyloidbeta in vivo / Neuron 58 : 42 ~ 51
Del Prete D / 2014 / APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that
Fogel H / 2014 / APP homodimers transduce an amyloid-beta-mediated increase in release probability at excitatory synapses / Cell Rep 7 : 1560 ~ 1576
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