지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 233 - 234 (2page)
이용수
초록· 키워드
오류제보하기
Aberrant expression of the polypeptide N-acetyl-galactosaminyltransferase (GALNTs) has been associated with cancer, but their function(s) in metastasis remains elusive. We have recently identified GALNT14, one of the O-GalNAc glycosylationinitiating enzymes, as a prognostic marker for pulmonary relapse in breast cancer patients. Furthermore, we showed that GALNT14 promotes lung metastasis by the following novel mechanisms: 1) enhancing metastasis initiation by inhibiting the anti-metastatic effect of BMP produced from the lung stroma, 2) exploiting growth signals (e.g. FGF) supplied by macrophages, for their growth into macrometastases in the lung environment. These multi-faceted roles of GALNT14 in lung metastasis are achieved by GALNT14-mediated inhibition and activation of the BMP and FGF signaling pathways, respectively. The link among GALNT14, its downstream pathways and lung metastasis, provides us with an opportunity to develop effective therapeutic intervention for breast cancer.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
GPR78 promotes lung cancer cell migration and metastasis by activation of Gq-Rho GTPase pathway
BMB Reports
2016 .01
-
The study on survivability of Korean-American Lung cancer patients in SEER data with Kaplan Meier Method
대한인간공학회 학술대회논문집
2015 .10
-
유방암 전이 관련 핵심 유전자를 이용한 기계학습 예측 모델
한국정보과학회 학술발표논문집
2021 .06
-
Tubeimoside-1 suppresses breast cancer metastasis through downregulation of CXCR4 chemokine receptor expression
BMB Reports
2016 .01
-
Particulate matter promotes cancer metastasis through increased HBEGF expression in macrophages
Experimental and Molecular Medicine
2022 .11
-
Tumor regionalization after surgery: Roles of the tumor microenvironment and neutrophil extracellular traps
Experimental and Molecular Medicine
2022 .06
-
The Microfluidic Device for Investigating Effects of Interleukin-6 in Lymphatic Metastasis of Breast Cancer
한국생물공학회 학술대회
2023 .10
-
MicroRNAs: promising biomarkers for diagnosis and therapeutic targets in human colorectal cancer metastasis
BMB Reports
2015 .01
-
Cell heterogeneity and anisotropic movement are critical in cancer metastasis
한국고분자학회 학술대회 연구논문 초록집
2016 .10
-
딥러닝을 활용한 멀티모달 CT의 2D 조인트 히스토그램 기반 폐암 종류 분류
대한전자공학회 학술대회
2018 .06
-
Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis
Experimental and Molecular Medicine
2023 .05
-
Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer
Experimental and Molecular Medicine
2021 .10
-
Phospholipid dynamics in ex vivo lung cancer and normal lung explants
Experimental and Molecular Medicine
2021 .01
-
Novel discrimination system for lung cancer cell with virus based color structure
한국고분자학회 학술대회 연구논문 초록집
2015 .04
-
TP53I11 suppresses epithelial-mesenchymal transition and metastasis of breast cancer cells
BMB Reports
2019 .01
-
Extraction of Lung Tumor Regions from Thoracic CT Images Using An Improved U-Net
제어로봇시스템학회 국제학술대회 논문집
2023 .10
-
Downregulated CDK10 promotes cancer progression and radioresistance in lung cancer through activating the JNK/c-Jun signaling pathway
BMB Reports
2024 .07
-
MAPK4 silencing in gastric cancer drives liver metastasis by positive feedback between cancer cells and macrophages
Experimental and Molecular Medicine
2023 .02
-
An Optimized Deep Belief Network Model for Accurate Breast Cancer Classification
IEIE Transactions on Smart Processing & Computing
2020 .08
-
Nanocomposites of Immune Check Point Inhibitor for Theranostic Application of Pulmonary Metastasis of Cancer
한국생물공학회 학술대회
2023 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0