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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 91 - 96 (6page)
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Nuclear factor erythroid 2-related factor 2 (Nrf2) provides a cellular defense against oxidative stress by inducing the expression of antioxidant and detoxification enzymes. The calcium antagonist, verapamil, is an FDA-approved drug prescribed for the treatment of hypertension. Here, we show that verapamil acts as a potent Nrf2 activator without causing cytotoxicity, through degradation of Kelch-like ECH-associated protein 1 (Keap1), a Nrf2 repressor. Furthermore, verapamilinduced Keap1 degradation is prominently mediated by a p62-dependent autophagic pathway. Correspondingly, verapamil protects cells from acetaminophen-induced oxidative damage through Nrf2 activation. These results demonstrated the underlying mechanisms for the protective role of verapamil against acetaminophen-induced cytotoxicity.
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참고문헌 (25)
참고문헌 신청
Bae SH / 2013 / Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage / Cell Metab 17 : 73 ~ 84
Bataille AM / 2012 / Nrf2: a potential target for new therapeutics in liver disease / Clin Pharmacol Ther 92 : 340 ~ 348
Chan K / 2001 / An important function of Nrf2 in com
Copple IM / 2008 / The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system / Hepatology 48 : 1292 ~ 1301
Goldring CE / 2004 / Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice / Hepatology 39 : 1267 ~ 1276
Bataille AM / 2012 / Nrf2: a potential target for new therapeutics in liver disease / Clin Pharmacol Ther 92 : 340 ~ 348
Chan K / 2001 / An important function of Nrf2 in com
Copple IM / 2008 / The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system / Hepatology 48 : 1292 ~ 1301
Goldring CE / 2004 / Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice / Hepatology 39 : 1267 ~ 1276
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