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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 272 - 277 (6page)
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초록· 키워드
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Protein kinase CK2 downregulation induces premature senescence in various human cell types via activation of the reactive oxygen species (ROS)–p53–p21Cip1/WAF1 pathway. The transcription factor “nuclear factor erythroid 2-related factor 2” (Nrf2) plays an important role in maintaining intracellular redox homeostasis. In this study, Nrf2 overexpression attenuated CK2 downregulation– induced ROS production and senescence markers including SA--gal staining and activation of p53–p21Cip1/WAF1 in human breast (MCF-7) and colon (HCT116) cancer cells. CK2 downregulation reduced the transcription of Nrf2 target genes, such as glutathione S-transferase, glutathione peroxidase 2, and glutathione reductase 1. Furthermore, CK2 downregulation destabilized Nrf2 protein via inhibiting autophagic degradation of Kelch-like ECHassociated protein 1 (Keap1). Finally, CK2 downregulation decreased the nuclear import of Nrf2 by deactivating AMP-activated protein kinase (AMPK). Collectively, our data suggest that both Keap1 stabilization and AMPK inactivation are associated with decreased activity of Nrf2 in CK2 downregulation–induced cellular senescence.
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참고문헌 (23)
참고문헌 신청
Campisi J / 2013 / Aging, cellular senescence, and cancer / Annu Rev Physiol 75:685~705
Kuilman T / 2010 / The essence of senescence / Genes Dev 24:2463~2479
Dimri GP / 1995 / A biomarker that identifies senescent human cells in culture and in aging skin in vivo / Proc Natl Acad Sci U S A 92:9363~9367
Coppé JP / 2010 / The senescence-associated secretory phenotype : the dark side of tumor suppression / Annu Rev Pathol 5:99~118
Narita M / 2003 / Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence / Cell 113:703~716
Kuilman T / 2010 / The essence of senescence / Genes Dev 24:2463~2479
Dimri GP / 1995 / A biomarker that identifies senescent human cells in culture and in aging skin in vivo / Proc Natl Acad Sci U S A 92:9363~9367
Coppé JP / 2010 / The senescence-associated secretory phenotype : the dark side of tumor suppression / Annu Rev Pathol 5:99~118
Narita M / 2003 / Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence / Cell 113:703~716
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