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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 507 - 512 (6page)
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초록· 키워드
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In the present study, we addressed the question of whether treatment with mannitol, an osmotic diuretic, affects astrogliovascular responses to status epilepticus (SE). In saline-treated animals, astrocytes exhibited reactive astrogliosis in the CA1-3 regions 2-4 days after SE. In the mannitol-treated animals, a large astroglial empty zone was observed in the CA1 region 2 days after SE. This astroglial loss was unrelated to vasogenic edema formation. There was no difference in SE-induced neuronal loss between saline- and mannitol-treated animals.
Furthermore, mannitol treatment did not affect astroglial loss and vasogenic edema formation in the dentate gyrus and the piriform cortex. These findings suggest that mannitol treatment induces selective astroglial loss in the CA1 region independent of vasogenic edema formation following SE. These findings support the hypothesis that the susceptibility of astrocytes to SE is most likely due to the distinctive heterogeneity of astrocytes independent of hemodynamics.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Baran H / 1987 / Effect of mannitol treatment on brain neurotransmitter markers in kainic acid-induced epilepsy / Neuroscience 21 : 679 ~ 684
Emerson MR / 1999 / A global hypoxia preconditioning model: neuroprotection against seizure-induced specific gravity changes (edema) and brain damage in rats / Brain Res Bra
Hartwell RC / 1993 / Mannitol, intracranial pressure, and vasogenic edema / Neurosurgery 32 : 444 ~ 450
Kang TC / 2006 / Epileptogenic roles of astroglial death and regeneration in the dentate gyrus of experimental temporal lobe epilepsy / Glia 54 : 258 ~ 271
Kastrup A / 2008 / Early disruption of the blood-brain barrier after thrombolytic therapy predicts hemorrhage in patients with acute stroke / Stroke 39 : 2385 ~ 2387
Emerson MR / 1999 / A global hypoxia preconditioning model: neuroprotection against seizure-induced specific gravity changes (edema) and brain damage in rats / Brain Res Bra
Hartwell RC / 1993 / Mannitol, intracranial pressure, and vasogenic edema / Neurosurgery 32 : 444 ~ 450
Kang TC / 2006 / Epileptogenic roles of astroglial death and regeneration in the dentate gyrus of experimental temporal lobe epilepsy / Glia 54 : 258 ~ 271
Kastrup A / 2008 / Early disruption of the blood-brain barrier after thrombolytic therapy predicts hemorrhage in patients with acute stroke / Stroke 39 : 2385 ~ 2387
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