지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 106 - 118 (13page)
이용수
초록· 키워드
오류제보하기
How the organ size is adjusted to the proper size during development and how organs know that they reach the original size during regeneration remain long-standing questions. Based on studies using multiple model organisms and approaches for over 20 years, a consensus has been established that the Hippo pathway plays crucial roles in controlling organ size and maintaining tissue homeostasis. Given the significance of these processes, the dysregulation of the Hippo pathway has also implicated various diseases, such as tissue degeneration and cancer. By regulating the downstream transcriptional coactivators YAP and TAZ, the Hippo pathway coordinates cell proliferation and apoptosis in response to a variety of signals including cell contact inhibition, polarity, mechanical sensation and soluble factors. Since the core components and their functions of the Hippo pathway are evolutionarily conserved, this pathway serves as a global regulator of organ size control. Therefore, further investigation of the regulatory mechanisms will provide physiological insights to better understand tissue homeostasis. In this review, the historical developments and current understandings of the regulatory mechanism of Hippo signaling pathway are discussed.
목차
등록된 정보가 없습니다.
참고문헌 (152)
참고문헌 신청
Shingleton AW / 2010 / The regulation of organ size in Drosophila: physiology, plasticity, patterning and physical force / Organogenesis 6:76~87
Gokhale RH / 2015 / Size control: the developmental physiology of body and organ size regulation / Wiley Interdiscip Rev Dev Biol 4:335~356
Halder G / 2011 / Hippo signaling: growth control and beyond / Development 138:9~22
Twitty VCS / 1931 / The growth of eyes and limbs transplanted heteroplastically between two species of Amblystoma / J Exp Zool 59:61~86
Michalopoulos GK / 1997 / Liver regeneration / Science 276:60~66
Gokhale RH / 2015 / Size control: the developmental physiology of body and organ size regulation / Wiley Interdiscip Rev Dev Biol 4:335~356
Halder G / 2011 / Hippo signaling: growth control and beyond / Development 138:9~22
Twitty VCS / 1931 / The growth of eyes and limbs transplanted heteroplastically between two species of Amblystoma / J Exp Zool 59:61~86
Michalopoulos GK / 1997 / Liver regeneration / Science 276:60~66
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The role of extracellular biophysical cues in modulating the Hippo-YAP pathway
BMB Reports
2017 .01
-
Regulation of the Hippo signaling pathway by ubiquitin modification
BMB Reports
2018 .01
-
Hippo signaling: Special issue of BMB Reports in 2018
BMB Reports
2018 .01
-
Upstream paths for Hippo signaling in Drosophila organ development
BMB Reports
2018 .01
-
Regulation and Regulators of the Hippo-YAP/TAZ Pathway
한국생물공학회 학술대회
2016 .10
-
Regulation of Hippo signaling by actin remodeling
BMB Reports
2018 .01
-
HiPPO 메모리 프레임워크를 사용한 궤적 기반 모방학습
정보 및 제어 논문집
2024 .10
-
A novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development
BMB Reports
2021 .01
-
Insulin receptor substrate 2: a bridge between Hippo and AKT pathways
BMB Reports
2018 .01
-
Hippo-YAP/TAZ signaling in angiogenesis
BMB Reports
2018 .01
-
Dishevelling Wnt and Hippo
BMB Reports
2018 .01
-
The potential role of YAP in head and neck squamous cell carcinoma
Experimental and Molecular Medicine
2020 .08
-
Clinical implications of the Hippo-YAP pathway in multiple cancer contexts
BMB Reports
2018 .01
-
Interacting network of Hippo, Wnt/β-catenin and Notch signaling represses liver tumor formation
BMB Reports
2017 .01
-
Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer
BMB Reports
2017 .06
-
Linear time-varying modeling of inter-organ regulatory system
제어로봇시스템학회 국제학술대회 논문집
2022 .11
-
Design of Novel Biosynthetic Pathways for the Production of High Value-added Chemicals
한국생물공학회 학술대회
2015 .04
-
DNA binding partners of YAP/TAZ
BMB Reports
2018 .01
-
Effect of PFKFB3 on YAP-TEAD Interaction
한국생물공학회 학술대회
2024 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0