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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 126 - 133 (8page)
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초록· 키워드
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Hippo signaling plays critical roles in regulation of tissue homeostasis, organ size, and tumorigenesis by inhibiting YES-associated protein (YAP) and PDZ-binding protein TAZ through MST1/2 and LATS1/2 pathway. It is also engaged in cross-talk with various other signaling pathways, including WNT, BMPs, Notch, GPCRs, and Hedgehog to further modulate activities of YAP/TAZ. Because YAP and TAZ are transcriptional coactivators that lack DNA-binding activity, both proteins must interact with DNA-binding transcription factors to regulate target gene’s expression. To activate target genes involved in cell proliferation, TEAD family members are major DNA-binding partners of YAP/TAZ. Accordingly, YAP/TAZ were originally classified as oncogenes. However, YAP might also play tumor-suppressing role. For example, YAP can bind to DNA-binding tumor suppressors including RUNXs and p73. Thus, YAP might act either as an oncogene or tumor suppressor depending on its binding partners. Here, we summarize roles of YAP depending on its DNA-binding partners and discuss context-dependent functions of YAP/TAZ.
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참고문헌 (98)
참고문헌 신청
Saucedo LJ / 2007 / Filling out the Hippo pathway / Nat Rev Mol Cell Biol 8:613~621
Harvey K / 2007 / The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network / Nat Rev Cancer 7:182~191
Zhao B / 2007 / Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control / Genes Dev 21:2747~2761
Camargo FD / 2007 / YAP1 increases organ size and expands undifferentiated progenitor cells / Curr Biol 17:2054~2060
Dong J / 2007 / Elucidation of a universal size-control mechanism in Drosophila and mammals / Cell 130:1120~1133
Harvey K / 2007 / The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network / Nat Rev Cancer 7:182~191
Zhao B / 2007 / Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control / Genes Dev 21:2747~2761
Camargo FD / 2007 / YAP1 increases organ size and expands undifferentiated progenitor cells / Curr Biol 17:2054~2060
Dong J / 2007 / Elucidation of a universal size-control mechanism in Drosophila and mammals / Cell 130:1120~1133
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