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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 134 - 142 (9page)
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Organ growth is fundamental to animal development. One of major mechanisms for growth control is mediated by the conserved Hippo signaling pathway initially identified in Drosophila. The core of this pathway in Drosophila consists of a cascade of protein kinases Hippo and Warts that negatively regulate transcriptional coactivator Yorkie (Yki). Activation of Yki promotes cell survival and proliferation to induce organ growth. A key issue in Hippo signaling is to understand how core kinase cascade is activated. Activation of Hippo kinase cascade is regulated in the upstream by at least two transmembrane proteins Crumbs and Fat that act in parallel. These membrane proteins interact with additional factors such as FERM-domain proteins Expanded and Merlin to modulate subcellular localization and function of the Hippo kinase cascade. Hippo signaling is also influenced by cytoskeletal networks and cell tension in epithelia of developing organs. These upstream events in the regulation of Hippo signaling are only partially understood. This review focuses on our current understanding of some upstream processes involved in Hippo signaling in developing Drosophila organs.
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참고문헌 (92)
참고문헌 신청
Rieder LE / 2014 / Wisdom from the fly / Trends Genet 30:479~481
Xu T / 1995 / Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase / Development 121:1053~1063
Justice RW / 1995 / The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation / Genes Dev 9:534~546
Tapon N / 2002 / salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines / Cell 110:67~78
Harvey KF / 2003 / The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis / Cell 114:457~467
Xu T / 1995 / Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase / Development 121:1053~1063
Justice RW / 1995 / The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation / Genes Dev 9:534~546
Tapon N / 2002 / salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines / Cell 110:67~78
Harvey KF / 2003 / The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis / Cell 114:457~467
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The role of extracellular biophysical cues in modulating the Hippo-YAP pathway
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Hippo-YAP/TAZ signaling in angiogenesis
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Insulin receptor substrate 2: a bridge between Hippo and AKT pathways
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Dishevelling Wnt and Hippo
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Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer
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해석방법 및 연소가스특성 적용에 따른 로켓 노즐 대류열전달계수의 매개변수적 비교 고찰
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Drosophila as a model for unfolded protein response research
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Drosophila blood as a model system for stress sensing mechanisms
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Effect of PFKFB3 on YAP-TEAD Interaction
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