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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 548 - 553 (6page)
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Mesenchymal stem cells (MSCs) are widely used in cartilage tissue engineering to repair articular cartilage defects. However, hypertrophy of chondrocytes derived from MSCs might hinder the stabilization of hyaline cartilage. Thus, it is very important to find a suitable way to maintain the chondrogenic phenotype of chondrocytes. It has been reported that cordycepin has anti-inflammatory and anti-tumor functions. However, the role of cordycepin in chondrocyte hypertrophy remains unclear.
Therefore, the objective of this study was to determine the effect of cordycepin on chondrogenesis and chondrocyte hypertrophy in MSCs and ATDC5 cells. Cordycepin upregulated chondrogenic markers including Sox9 and collagen type II while down-regulated hypertrophic markers including Runx2 and collagen type X. Further exploration showed that cordycepin promoted chondrogenesis through inhibiting Nrf2 while activating BMP signaling. Besides, cordycepin suppressed chondrocyte hypertrophy through PI3K/Bapx1 pathway and Notch signaling. Our results indicated cordycepin had the potential to maintain chondrocyte phenotype and reconstruct engineered cartilage.
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등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Madry H / 2014 / Tissue-engineering strategies to repair joint tissue in osteoarthritis: nonviral gene-transfer approaches / Curr Rheumatol Rep 16:450
Mardones R / 2015 / Cell Therapy and Tissue Engineering Approaches for Cartilage Repair and/or Regeneration / Int J Stem Cells 8:48~53
Caldwell KL / 2015 / Cell-based articular cartilage repair: the link between development and regeneration / Osteoarthritis Cartilage 23:351~362
He B / 2014 / Designer functionalised self-assembling peptide nanofibre scaffolds for cartilage tissue engineering / Expert Rev Mol Med 16:e12
Sun AX / 2015 / Projection Stereolithographic Fabrication of Human Adipose Stem Cell-Incorporated Biodegradable Scaffolds for Cartilage Tissue Engineering / Front Bioeng Biotechnol 3:115
Mardones R / 2015 / Cell Therapy and Tissue Engineering Approaches for Cartilage Repair and/or Regeneration / Int J Stem Cells 8:48~53
Caldwell KL / 2015 / Cell-based articular cartilage repair: the link between development and regeneration / Osteoarthritis Cartilage 23:351~362
He B / 2014 / Designer functionalised self-assembling peptide nanofibre scaffolds for cartilage tissue engineering / Expert Rev Mol Med 16:e12
Sun AX / 2015 / Projection Stereolithographic Fabrication of Human Adipose Stem Cell-Incorporated Biodegradable Scaffolds for Cartilage Tissue Engineering / Front Bioeng Biotechnol 3:115
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