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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 132 - 137 (6page)
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Elevated glucose levels in cancer cells can be attributed to increased levels of glucose transporter (GLUT) proteins. Glut1 expression is increased in human malignant cells. To investigate alternative roles of Glut1 in breast cancer, we silenced Glut1 in triple-negative breast-cancer cell lines using a short hairpin RNA (shRNA) system. Glut1 silencing was verified by Western blotting and qRT-PCR. Knockdown of Glut1 resulted in decreased cell proliferation, glucose uptake, migration, and invasion through modulation of the EGFR/ MAPK signaling pathway and integrin 1/Src/FAK signaling pathways. These results suggest that Glut1 not only plays a role as a glucose transporter, but also acts as a regulator of signaling cascades in the tumorigenesis of breast cancer.
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참고문헌 (27)
참고문헌 신청
Altenberg B / 2004 / Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes / Genomics 84 : 1014 ~ 1020
Badve S / 2011 / Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists / Mod Pathol 24 : 157
Baldin V / 1993 / Cyclin D1 is a nuclear protein required for cell cycle progression in G1 / Genes Dev 7 : 812 ~ 821
Brenton JD / 2005 / Molecular classification and molecular forecasting of breast cancer: ready for clinical application? / J Clin Oncol 23 : 7350 ~ 7360
Cairns RA / 2011 / Regulation of cancer cell metabolism / Nat Rev Cancer 11 : 85 ~ 95
Badve S / 2011 / Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists / Mod Pathol 24 : 157
Baldin V / 1993 / Cyclin D1 is a nuclear protein required for cell cycle progression in G1 / Genes Dev 7 : 812 ~ 821
Brenton JD / 2005 / Molecular classification and molecular forecasting of breast cancer: ready for clinical application? / J Clin Oncol 23 : 7350 ~ 7360
Cairns RA / 2011 / Regulation of cancer cell metabolism / Nat Rev Cancer 11 : 85 ~ 95
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