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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제19권 제1호
- 발행연도
- 2016.1
- 수록면
- 61 - 70 (10page)
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Purpose: Parenteral nutrition (PN)-associated cholestasis (PNAC) is one of the most common complications in very low birth weight infants (VLBWIs). The aim of this study is to evaluate the risk factors of PNAC in VBLWIs.Methods: We retrospectively reviewed the medical records of 322 VLBWIs admitted to the neonatal intensive care unit of our hospital from July 1, 2009 to December 31, 2013. We excluded 72 dead infants; 6 infants were transferred to another hospital, and 57 infants were transferred to our hospital at 2 weeks after birth. The infants were divided into the cholestasis and the non-cholestasis groups. PNAC was defined as a direct bilirubin level of ≥2.0 mg/dL in infants administered with PN for ≥2 weeks.Results: A total of 187 VLBWI were enrolled in this study; of these, 46 infants developed PNAC. Multivariate logistic regression analysis showed that the risk factors of PNAC in VLBWI were longer duration of antimicrobial use (odds ratio [OR] 4.49, 95% confidence interval [95% CI] 4.42-4.58), longer duration of PN (OR 2.68, 95% CI 2.41-3.00), long-term lack of enteral nutrition (OR 2.89, 95% CI 2.43-3.37), occurrence of necrotizing enterocolitis (OR 2.40, 95% CI 2.16-2.83), and gastrointestinal operation (OR 2.19, 95% CI 2.03-2.58).Conclusion: The results of this study suggest that shorter PN, aggressive enteral nutrition, and appropriate anti-microbial use are important strategies in preventing PNAC.
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참고문헌 (30)
참고문헌 신청
Jolin-Dahel K / 2013 / Parenteral nutrition- induced cholestasis in neonates: where does the problem lie / Gastroenterol Res Pract 2013:163632
Hsieh MH / 2009 / Parenteral nutrition-associated cholestasis in premature babies: risk factors and predictors / Pediatr Neonatol 50:202~207
McKiernan PJ / 2002 / Neonatal cholestasis / Semin Neonatol 7:153~165
Hofmann AF / 1995 / Defective biliary secretion during total parenteral nutrition: probable mechanisms and possible solutions / J Pediatr Gastroenterol Nutr 20:376~390
Chen CY / 2009 / The risk factors of parenteral nutrition- associated cholestasis in preterm infants / Pediatr Neonatol 50:181~183
Hsieh MH / 2009 / Parenteral nutrition-associated cholestasis in premature babies: risk factors and predictors / Pediatr Neonatol 50:202~207
McKiernan PJ / 2002 / Neonatal cholestasis / Semin Neonatol 7:153~165
Hofmann AF / 1995 / Defective biliary secretion during total parenteral nutrition: probable mechanisms and possible solutions / J Pediatr Gastroenterol Nutr 20:376~390
Chen CY / 2009 / The risk factors of parenteral nutrition- associated cholestasis in preterm infants / Pediatr Neonatol 50:181~183
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