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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 177 - 191 (15page)
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초록· 키워드
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Objectives
To evaluate the effect of InsamGobonHwan (IGH) on growth of rats.
Methods
We divided male Sprague-Dawley rats into 4 groups(IGHE1, IGHE2, IGHE3 and sham group). IGHE1, IGHE2, IGHE3 groups were administered with IGHE water extracts once a day at the dose of 1,000, 500 and 250㎎/㎏/10㎖ for 1 week, 2 weeks, and 3 weeks. Sham group was administered with normal saline with using the same method. We measured body weight, amount of body weight increasing, length of femur, serum Growth Hormone(GH), serum Insulin-like Growth Factor-Ⅰ(IGF-Ⅰ), serum Thyroid-stimulating Hormone(TSH) and serum testosterone at 1 week, 2 weeks, and 3 weeks of experiment.
Results
The body weight and the changes of body weight increased significantly in IGHE1 group compared to sham group after 2 and 3 weeks, and in IGHE2 group after 2 weeks. The lengths of the femur increased significantly in IGHE1 group as compared with sham group after 1, 2 and 3 weeks, and in IGHE3 group after 1 week. The level of IGF-Ⅰ in the serum increased significantly in S1 group as compared tosham group after 1 and 3 weeks, and in IGHE13 group after 3 weeks. The level of TSH in the serum increased significantly in IGHE1group as compared to sham group after 2 and 3 weeks. The level of GH and testosterone in the serum does not change significantly.
Conclusions
SGT have an effect of promoting growth of rats and might be effect to treat various kinds of growth delay in children.
목차
등록된 정보가 없습니다.
참고문헌 (46)
참고문헌 신청
Baxer RC / 1986 / Radioimmunoassay of growth hormone dependent insulin like growth factor binding protein in human plasma / J Clin Invest : 1504 ~ 1512
Cohen P / 2002 / American
GH Research Society / 2000 / Consensus guidelines for the diagnosis and treatement of growth hormone(GH) deficiency in childhood and adolescence: summary statement of the GH
Green H / 1985 / A dual effector theory of growth hormone action / Differentiation 29 (3) : 195 ~ 198
Rakover Y / 2000 / Comparison between four immunoassays for growth hormone(GH) measurement as guides to clinical decisions following GH provocative tests / J. Pediatr. Endoc
Cohen P / 2002 / American
GH Research Society / 2000 / Consensus guidelines for the diagnosis and treatement of growth hormone(GH) deficiency in childhood and adolescence: summary statement of the GH
Green H / 1985 / A dual effector theory of growth hormone action / Differentiation 29 (3) : 195 ~ 198
Rakover Y / 2000 / Comparison between four immunoassays for growth hormone(GH) measurement as guides to clinical decisions following GH provocative tests / J. Pediatr. Endoc
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