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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 19 - 34 (16page)
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Effect of Jowonsangamibang on the Growth of the Rats
Kim Bong Sung, Seo Jung Min, Baek Jung Han
Department of pediatrics, College of Oriental Medicine, Daegu Haany University
Objective : The purpose of this study is to find out the effect of Jowonsangamibang(JWS) on the growth of rats.
Methods : First of all, we divided male Sprague-Dawley rats into 4 groups(J1, J2, J3 and sham group). Then J1, J2 and J3 groups were administered with JWS water extracts(JWSE) once a day at a dosage 250, 500, 1,000㎎/㎏ respectively for 3 weeks. The sham group was administered with normal saline in the same manner. And we measured body weight, amount of body weight increased, length of femur, serum GH, serum IGF-Ⅰ, serum TSH and serum testosterone after each week.
Results : There were no significant changes of body weight, the level of GH, TSH, and testosterone in J1, J2 and J3 groups. The change of body weight gained was increased significantly in the J3 group compared with the sham group after 1, 2 and 3 weeks. The length of the femur was increased significantly in the J2 group after 1 week and in the J3 group after 3 weeks compared with the sham group. The level of IGF-Ⅰ in the serum was increased significantly in J1, J3 after 1 week compared with the sham group.
Conclusion : According to the results above, JWS increased body weight, length of femur, serum GH, serum IGF-1 compared with the sham group. This study shows that JWS has an effect on promoting the growth of rats, thus it's expected to treat of growth delay in children.
Key words : Jowonsangamibang(JWS), growth, body weight, length of the femur, GH, IGF-Ⅰ, TSH
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참고문헌 (42)
참고문헌 신청
/ 1975 / Review of medical physilogy : 305 ~ 7
/ 1985 / 臟腑辨證論治 : 201 ~ 45
/ 1986 / 幼科發揮大全 : 7 ~ 8
/ 1990 / The pubertal growth spurt in eight patients with true precocious puberty and growth hormone deficiency evidence for a direct role of sex steroids Journal of Clinica
/ 1993 / the effects of testosterone and dihydrotestosterone on growth hormone and insuline-like growth factor Ⅰ in the treatment of short stature and delayed puberty Journ
/ 1985 / 臟腑辨證論治 : 201 ~ 45
/ 1986 / 幼科發揮大全 : 7 ~ 8
/ 1990 / The pubertal growth spurt in eight patients with true precocious puberty and growth hormone deficiency evidence for a direct role of sex steroids Journal of Clinica
/ 1993 / the effects of testosterone and dihydrotestosterone on growth hormone and insuline-like growth factor Ⅰ in the treatment of short stature and delayed puberty Journ
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