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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 97 - 107 (11page)
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초록· 키워드
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Inhibitory Effects of Jojoongikgi-tang on the Secretion of PGE2 and NO and Cytokines in LPS-stimulated BV2 Microglial Cells
Lee Jun Moon, Lyu Sun Ae, Lee Seung Yeon*, Kim Bo Kyung**, Ko Woo Shin***
Department of Pediatrics, College of Oriental Medicine, Dong-Eui University
*Department of Pediatrics, College of Oriental Medicine, Dong-Eui University
**Clinical Research Center of Oriental Medicine, Dong-Eui University
Department of Neuropsychiatry, College of Oriental Medicine, Dong-Eui University
***Department of Oriental Medical Ophthalmology & Otolaryngology &Dermatology, College of Oriental Medicine, Dong-Eui University
Objectives
This experiment is about Jojoongikgi-tang(JIT) exerts anti-inflammatory effects in BV2 microglial cells, and the effect of JIT on Nitric oxide(NO) production in lipopolysaccharide(LPS)-stimulated BV2 microglial cells were also demonstrated.
Methods
To investigate the anti-inflammatory effects of JIT, NO production, expression level of iNOS mRNA, PGE2 synthesis, expression COX-2 mRNA, cell viability, TNF-α mRNA expression were examined.
Results
The expression level of inducible nitric oxide synthase(iNOS) was decreased by JIT, and the production of Prostaglandin E2(PGE2) and the expression of Cox-2 mRNA also were inhibited by JIT. Proinflammatory mediators, such as TNF-α, IL-1β, IL-12, were inhibited by JIT in a dose-dependent manner.
Conclusions
JIT have anti-inflammatory effects in BV2 microglial cells and could be used in inflammatory disease.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
/ / Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 1991 : 1557 ~ 8
/ / Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992 : 3051 ~ 64
/ / Nitric oxide: Physiology, pathophysiology, and pharmacology : 109 ~ 42
/ / Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon g and bacterial lipopolysaccharide. J. Exp. Med. 1993 :
/ / Role of inducible cyclooxygenase : 17 ~ 2 23
/ / Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992 : 3051 ~ 64
/ / Nitric oxide: Physiology, pathophysiology, and pharmacology : 109 ~ 42
/ / Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon g and bacterial lipopolysaccharide. J. Exp. Med. 1993 :
/ / Role of inducible cyclooxygenase : 17 ~ 2 23
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