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자료유형
학술저널
저자정보
저널정보
대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제19권 제1호
발행연도
2014.1
수록면
32 - 35 (4page)

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Purpose: Growth hormone (GH) plays a key role in the regulation of bodycomposition, lipid metabolism, and quality of life in adults with GH deficiency (GHD). This study investigated changes in laboratory findings and body compositionafter GH recommencement for adult GHD and analyzed correlation between GHinterruption period and endocrine or anthropometric parameters. Methods: A total of 45 patients (17 females and 28 males) diagnosed withchildhood-onset GHD (CO-GHD) were investigated and all patients had organicbrain lesions. Patients diagnosed CO-GHD were retested to confirm adult GHD atage 20.4±5.0 years (18.0–32.1 years). Recombinant human GH was administered ata dose of 0.44 mg/day. Clinical and laboratory parameters such as weight, height,body mass index (BMI), serum insulin-like growth factor 1 (IGF-1), serum totalcholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein(LDL) cholesterol, and triglyceride levels, were compared between baseline and12 months after treatment using paired t-test. In addition, correlation between GHinterruption period and clinical parameters including BMI, lipid profile, IGF-1, andIGFBP-3, was analyzed. Results: Of 45 patients, 33 patients had GH interruption period of 4.3±3.6 years(0.7–12.5 years). Serum HDL-cholesterol level increased significantly, whereas LDLcholesteroldecreased after 1 year of GH replacement therapy. However, bodyweight and BMI showed no significant changes after 1 year of GH replacementtherapy. There were no significant correlations between GH interruption period andlipid profile or anthropometric parameters. Conclusion: BMI and body weight were not affected by GH replacement. However,GH replacement in adults with GHD offers benefits in lipid metabolism.

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