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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Department of Neurology, College of Medicine and Neuroscience Research Institute in Medical Research Center, Seoul National University, Seoul
Objectives: The mechanism of neuroprotection of ion channel blockers against delayed neuronal death in global cerebral ischemia is not clear. We aimed to investigate whether neuroprotective effect of flunarizine (FNR) on global cerebral ischemia is related to Bcl-2/Bax and caspase-3 activity. Methods: Global ischemia was induced in Mongolian gerbils for 5 min. Animals were randomly assigned to ischemic control and FNR (10 mg/kg)-treated (intraperitoneal injection 30 min before ischemia) groups. Viable neuronal cells, Bcl-2/Bax expression and caspase- 3 activity in the area of hippocampus were compared between two groups. Results: Only at day 7, viable neuronal cells in CA1 were more prominent in FNR-treated group compared to control (p=0.02). Bcl-2/Bax expression and caspase-3 activity were not different between two groups. Conclusions: This data suggest that the neuroprotective mechanism of FNR against delayed neuronal death in transient global ischemia in gerbils is not associated with Bcl-2/Bax and caspase-3 activity.
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