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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 212 - 218 (7page)
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초록· 키워드
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Background/Aims: The aim of our study was to define the potential role of virologic response at 12months of treatment (VR12) in predicting subsequent virologic and clinical outcomes in adefovir (ADV)-treated lamivudine-resistant chronic hepatitis B. Methods: Two hundred and four patients with lamivudine-resistant chronic hepatitis B virus (HBV) treated with ADV monotherapy were included. Serum HBV DNA was quantified by real-time polymerase chain reactions. VR12was defined as a HBV DNA level of less than 4 log10copies/mL after 12 months of ADV treatment.
Results: VR12 was observed in 110 of the 204 patients (54%). The mean HBV DNA reductions from baseline after 12 months of ADV treatment were 3.8and 1.9 log10 copies/mL in patients with and without VR12, respectively (p＜0.001). The hepatitis B “e” antigen (HBeAg) seroconversion rates in patients with and without VR12 were 32% and 14% at 12 months treatment,respectively (p=0.018), and 40% and 27% at 24months of treatment (p=0.032). The genotypic mutation rates to ADV in patients with and without VR12were 0% and 6% at 12 months of treatment, respectively (p=0.033), and 21% and 42% at 24 months (p=0.012). The rates of viral breakthrough in patients with and without VR12 were 0% and 7% at 12 months of treatment, respectively (p=0.072), and 9% and 25% at 24 months (p=0.006). Conclusions: Patients without VR12 may need to switch to or add on other potent antiviral drugs in their medical regimens.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Angus P / 2003 / Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase / Gastroenterology 125 : 292 ~ 297
Berg T / 2003 / Prediction of treatment outcome in patients with chronic hepatitis C: significance of baseline parameters and viral dynamics duringtherapy / Hepatology 37 :
Buti M / 2001 / Quantitative hepatitis B virus DNA testing for the early prediction of the maintenanceof response during lamivudine therapy in patients with chronic hepatitis
Gauthier J / 1999 / Quantitation of hepatitis B viremia and emergence of YMDD variants in patients with chronic hepatitis B treated with lamivudine / J Infect Dis 180 : 1757
Hadziyannis SJ / 2005 / Long-term therapy with a
Berg T / 2003 / Prediction of treatment outcome in patients with chronic hepatitis C: significance of baseline parameters and viral dynamics duringtherapy / Hepatology 37 :
Buti M / 2001 / Quantitative hepatitis B virus DNA testing for the early prediction of the maintenanceof response during lamivudine therapy in patients with chronic hepatitis
Gauthier J / 1999 / Quantitation of hepatitis B viremia and emergence of YMDD variants in patients with chronic hepatitis B treated with lamivudine / J Infect Dis 180 : 1757
Hadziyannis SJ / 2005 / Long-term therapy with a
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