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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 657 - 664 (8page)
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Background/Aims: Quantification of hepatitis B surface antigen (HBsAg) is an emerging serologic test and may be useful for identifying treatment strategies for chronic hepatitis B (CHB). This study aimed to evaluate HBsAg titers during the natural course of CHB and identify correlations between HBsAg titers and hepatitis B virus (HBV) DNA concentrations across different CHB phases measured using an immunoradiometric assay (IRMA). Methods: CHB phases were defined on the basis of HBV DNA concentrations, the presence of hepatitis B e antigen/antibody (HBeAg/Ab) and serum alanine aminotransferase levels. Serum HBsAg titers and paired HBV DNA concentrations in the different phases of CHB were compared using 627 serum samples. Results: Mean HBsAg titers were significantly higher in the immunotolerant (IT) phase and immunoreactive (IR) HBeAg-positive phase than in the low-replicative (LR) and HBeAg-negative CHB (ENH) states. The correlation between HBsAg titers and HBV DNA concentrations was modest in the IT (n=36, r=0.804, p<0.001) and IR (n=48, r=0.773, p<0.001) phases, and it was poor in the LR state (n=116, r=0.289, p=0.002); however, no significant correlation was observed in the ENH state (n=67, r=0.146, p=0.237) or in the oral nucleos(t)ide analogue-treated group (n=267). Conclusions: HBsAg quantification using IRMA might be useful for discriminating different CHB phases and different stages of chronic liver disease.
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참고문헌 (22)
참고문헌 신청
Chan HL / 2010 / A longitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B / Hepatology 52 : 1232 ~ 1241
Chan HL / 2011 / Prediction of off-treatment response to lamivudine by serum hepatitis B surface antigen quantification in hepatitis B e antigen-negative patients / Antivir
European Association for the Study of the Liver / 2009 / EASL clinical practice guidelines: management of chronic hepatitis B / J Hepatol 50 : 227 ~ 242
European Association for the Study of the Liver / 2012 / EA
Ganji A / 2011 / Correlation between HBsAg quantitative assay results and HBV DNA levels in chronic HBV / Hepat Mon 11 : 342 ~ 345
Chan HL / 2011 / Prediction of off-treatment response to lamivudine by serum hepatitis B surface antigen quantification in hepatitis B e antigen-negative patients / Antivir
European Association for the Study of the Liver / 2009 / EASL clinical practice guidelines: management of chronic hepatitis B / J Hepatol 50 : 227 ~ 242
European Association for the Study of the Liver / 2012 / EA
Ganji A / 2011 / Correlation between HBsAg quantitative assay results and HBV DNA levels in chronic HBV / Hepat Mon 11 : 342 ~ 345
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