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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 842 - 850 (9page)
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초록· 키워드
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Background/Aims: The aim of this study was to establish a pathogenetic mechanism of pancreatitis in celiac disease and IgG4-related disease using gluten-sensitive human leukocyte antigen (HLA)-DQ8 transgenic mice. Methods: Transgenic mice expressing HLA-DQ8 genes were utilized.
Control mice were not sensitized but were fed gliadin-free rice cereal. Experimental groups consisted of gliadin-sensitized and gliadin-challenged mice; nonsensitized mice with cerulein hyperstimulation; and gliadin-sensitized and gliadinchallenged mice with cerulein hyperstimulation. Results: Gliadin-sensitized and gliadin-challenged mice with cerulein hyperstimulation showed significant inflammatory cell infiltrates, fibrosis and acinar atrophy compared with the control mice and the other experimental groups. The immunohistochemical analysis showed greater IgG1-positive plasma cells in the inflammatory infiltrates of gliadin-sensitized and gliadin-challenged mice with cerulein hyperstimulation compared with the control mice and the other experimental groups. Gliadin-sensitized and gliadin-challenged mice with cerulein hyperstimulation or gliadin-sensitized and gliadinchallenged mice showed IgG1-stained inflammatory cell infiltrates in the extrapancreatic organs, including the bile ducts, salivary glands, kidneys, and lungs. Conclusions: Gliadinsensitization and cerulein hyperstimulation of gluten-sensitive HLA-DQ8 transgenic mice resulted in pancreatitis and extrapancreatic inflammation. This animal model suggests that chronic gliadin ingestion in a susceptible individual with the HLA-DQ8 molecule may be associated with pancreatitis and extrapancreatic inflammation.
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참고문헌 (33)
참고문헌 신청
Sollid LM / 2005 / Celiac disease genetics: current concepts and practical applications / Clin Gastroenterol Hepatol 3:843~851
Rostom A / 2006 / American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease / Gastroenterology 131:1981~2002
Ansaldi N / 1981 / Exocrine pancreatic insufficiency in celiac sprue / Gastroenterology 80:883
Barera G / 2001 / Macroamylasemia attributable to gluten-related amylase autoantibodies: a case report / Pediatrics 107:E93
Carroccio A / 1991 / Exocrine pancreatic function in children with coeliac disease before and after a gluten free diet / Gut 32:796~799
Rostom A / 2006 / American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease / Gastroenterology 131:1981~2002
Ansaldi N / 1981 / Exocrine pancreatic insufficiency in celiac sprue / Gastroenterology 80:883
Barera G / 2001 / Macroamylasemia attributable to gluten-related amylase autoantibodies: a case report / Pediatrics 107:E93
Carroccio A / 1991 / Exocrine pancreatic function in children with coeliac disease before and after a gluten free diet / Gut 32:796~799
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