지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 51 - 57 (7page)
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초록· 키워드
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Background/Aims: Differences in the Helicobacter pylori infection rate are not sufficient to clarify the dissimilarity of gastric cancer incidence between Myanmar and its neighboring countries. To better understand this trend, the H. pylori virulence gene cagA was characterized in Myanmar. Methods: Glutamate-proline-isoleucine-tyrosine-alanine (EPIYA) patterns and CagA multimerization (CM) motifs of cagA genotypes were examined by performing polymerase chain reactions and DNA sequencing. Results: Of 69 tested H. pylori strains, cagA-positive patients had significantly more severe histological scores in their antrum than cagA-negative patients. Sequence analysis revealed that 94.1% of strains had Western-type cagA containing an EPIYA motif (92.6%) or EPIYT motif (6.4%). The intestinal metaplasia scores in the antral of patients infected with the ABC and ABCC types of cagA were significantly higher than those of patients with AB-type cagA. Interestingly, in patients infected with H. pylori, 46.3% of strains with three EPIYA motifs contained two identical Western-typical CM motifs, and these patients showed significantly higher antrum inflammation scores than patients infected with two identical nontypical-CM motif strains (p=0.02). Conclusions: In Myanmarese strains, Western-type cagA was predominant. The presence of CM motifs and the proportion of multiple EPIYA-C segments might partially explain the intermediate gastric cancer risk found in Myanmar.
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참고문헌 (37)
참고문헌 신청
Sahara S / 2012 / Role of Helicobacter pylori cagA EPIYA motif and vacA genotypes for the development of gastrointestinal diseases in Southeast Asian countries: a meta-analysis / BMC Infect Dis 12:223
Sodhi JS / 2013 / Prevalence of Helicobacter pylori infection and the effect of its eradication on symptoms of functional dyspepsia in Kashmir, India / J Gastroenterol Hepatol 28:808~813
Myint T / 2015 / Prevalence of Helicobacter pylori infection and atrophic gastritis in patients with dyspeptic symptoms in Myanmar / World J Gastroenterol 21:629~636
Yamaoka Y / 2010 / Mechanisms of disease: Helicobacter pylori virulence factors / Nat Rev Gastroenterol Hepatol 7:629~641
Matsunari O / 2012 / Association between Helicobacter pylori virulence factors and gastroduodenal diseases in Okinawa, Japan / J Clin Microbiol 50:876~883
Sodhi JS / 2013 / Prevalence of Helicobacter pylori infection and the effect of its eradication on symptoms of functional dyspepsia in Kashmir, India / J Gastroenterol Hepatol 28:808~813
Myint T / 2015 / Prevalence of Helicobacter pylori infection and atrophic gastritis in patients with dyspeptic symptoms in Myanmar / World J Gastroenterol 21:629~636
Yamaoka Y / 2010 / Mechanisms of disease: Helicobacter pylori virulence factors / Nat Rev Gastroenterol Hepatol 7:629~641
Matsunari O / 2012 / Association between Helicobacter pylori virulence factors and gastroduodenal diseases in Okinawa, Japan / J Clin Microbiol 50:876~883
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