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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 358 - 369 (12page)
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Background/Aims: The cytosolic host protein nucleotide binding oligomerization domain 1 (Nod1) has emerged as a key pathogen recognition molecule for innate immune responses in epithelial cells. The purpose of the study was to elucidate the mechanism by which Helicobacter pylori infection leads to transepithelial neutrophil migration in a Nod1-mediated manner. Methods: Human epithelial cell lines AGS and Caco-2 were grown and infected with H. pylori. Interleukin (IL)-8 mRNA expression and IL-8 secretion were assessed, and nuclear factor kB (NF-kB) activation was determined. Stable transfections of AGS and Caco-2 cells with dominant negative Nod1 were generated. Neutrophil migration across the monolayer was quantified. Results: Cytotoxin-associated gene pathogenicity island (cagPAI)(+) H. pylori infection upregulated IL-8 mRNA expression and IL-8 secretion in AGS and Caco-2 cells compared with controls. NF-kB activation, IL-8 mRNA expression and IL-8 secretion by cagPAI knockdown strains were reduced compared with those infected with the wild-type strain. NF-kB activation, IL-8 mRNA expression and IL-8 secretion in dominant-negative (DN)-Nod1 stably transfected cells were reduced compared with the controls. The transepithelial migration of neutrophils in DN-Nod1 stably transfected cells was reduced compared with that in controls. Conclusions: Signaling through Nod1 plays an essential role in neutrophil migration induced by the upregulated NF-kB activation and IL-8 expression in H. pylori-infected human epithelial cells.
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참고문헌 (26)
참고문헌 신청
Allison CC / 2013 / Nucleotide oligomerization domain 1 enhances IFN-gamma signaling in gastric epithelial cells during Helicobacter pylori infection and exacerbates disease severity / J Immunol 190:3706~3715
Oikawa T / 2012 / Gene polymorphisms of NOD1 and interleukin-8 influence the susceptibility to erosive esophagitis in Helicobacter pylori infected Japanese population / Hum Immunol 73:1184~1189
Hidalgo IJ / 1989 / Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability / Gastroenterology 96:736~749
Nash S / 1987 / Effects of polymorphonuclear leukocyte transmigration on the barrier function of cultured intestinal epithelial monolayers / J Clin Invest 80:1104~1113
Backert S / 2004 / Functional analysis of the cag pathogenicity island in Helicobacter pylori isolates from patients with gastritis, peptic ulcer, and gastric cancer / Infec
Oikawa T / 2012 / Gene polymorphisms of NOD1 and interleukin-8 influence the susceptibility to erosive esophagitis in Helicobacter pylori infected Japanese population / Hum Immunol 73:1184~1189
Hidalgo IJ / 1989 / Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability / Gastroenterology 96:736~749
Nash S / 1987 / Effects of polymorphonuclear leukocyte transmigration on the barrier function of cultured intestinal epithelial monolayers / J Clin Invest 80:1104~1113
Backert S / 2004 / Functional analysis of the cag pathogenicity island in Helicobacter pylori isolates from patients with gastritis, peptic ulcer, and gastric cancer / Infec
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