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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 159 - 166 (8page)
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Background/Aims: The efficacy of surveillance for esophageal squamous cell neoplasia (ESCN) in patients with head and neck squamous cell carcinoma (HNSCC) remains controversial. Our study aimed to provide clinical data concerning the necessity of surveillance for detecting early ESCN in patients with HNSCC. Methods: We retrospectively reviewed the data from 714 patients who were pathologically confirmed as having HNSCC (n=236 oral cavity cancers, 137 oropharyngeal cancers, 87 hypopharyngeal cancers, and 254 laryngeal cancers). Results: Of 714 patients, during a median follow-up of 31 months, 48 ESCNs (37 synchronous and 11 metachronous) were detected in 36 patients (5%). Fifteen synchronous lesions (40.3%) were early ESCN, whereas nine metachronous lesions (81.8%) were early ESCN. The 3-year survival rates of HNSCC only and HNSCC combined with ESCN were 71.2% and 48.2%, respectively (p<0.001). Among 36 patients with ESCN, the 3-year survival rates for early and advanced ESCN were 77.7% and 21.7%, respectively (p=0.01). In the multivariate analysis, alcohol consumption and hypopharyngeal cancer were significant factors associated with the development of ESCN. Conclusions: HNSCC patients with early ESCN were similar in prognosis with patients without ESCN, in contrast to patients with advanced ESCN. Therefore, surveillance for the early detection of ESCN in patients with HNSCC, especially in alcohol drinkers and those with hypopharyngeal cancer, is warranted.
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참고문헌 (26)
참고문헌 신청
Aaltonen LA / 2000 / Pathology and genetics of tumours of the digestive system / IARC Press : 270 ~
Atabek U / 1990 / Impact of esophageal screening in patients with head and neck cancer / Am Surg 56 : 289 ~ 292
Berrino F / 1998 / Variation in survival of patients with head and neck cancer in Europe by the site of origin of the tumours. EUROCARE Working Group / Eur J Cancer 34 : 215
Chen MC / 2010 / Impact of second primary esophageal or lung cancer on survival of patients with head and neck cancer / Oral Oncol 46 : 249 ~ 254
Chuang SC / 2008 / Risk of second primary cancer among patients with head and neck cancers: a pooled analysis of 13 cancer registries / Int J Cancer 123 : 2390 ~ 2396
Atabek U / 1990 / Impact of esophageal screening in patients with head and neck cancer / Am Surg 56 : 289 ~ 292
Berrino F / 1998 / Variation in survival of patients with head and neck cancer in Europe by the site of origin of the tumours. EUROCARE Working Group / Eur J Cancer 34 : 215
Chen MC / 2010 / Impact of second primary esophageal or lung cancer on survival of patients with head and neck cancer / Oral Oncol 46 : 249 ~ 254
Chuang SC / 2008 / Risk of second primary cancer among patients with head and neck cancers: a pooled analysis of 13 cancer registries / Int J Cancer 123 : 2390 ~ 2396
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