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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 89 - 98 (10page)
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Pur po se : The prevalence of serotypes can be changed with respect to age of the patients,
regions and times of the surveillance. The aim of this study is to analyze changes in serotype
distribution of pneumococcal isolates from Korean pediatric patients.
Methods : Four hundred and sixty five strains of S. pneumoniae were isolated from
various clinical specimens at the Seoul National University Children's Hospital during a 15
year-period, from 1991 to 2005, were subjected to serotype and penicillin susceptibility. The
study period was divided into three 5 year-periods, 1991∼1995(period I), 1996∼2000(period
II), and 2001∼2005(period III).
Results : Common serotypes were 19F, 23F, 19A, 6B, 14, 6A and 9V in decreasing
orders of frequency, and these 7 serotypes accounted for 79% of total 465 strains. In the
serotype distribution of invasive infection isolates from children <60 months of age, similar
serotypes accounted for 70% of 101 strains. In total strains, the proportion of serotype 19A
and 6A increased, while that of serotype 19F and 14 decreased. The majority(75∼92%) of
vaccine types and cross-reactive types from invasive infection isolates was penicillin-resistant,
whereas 34.4% of non-vaccine types was penicillin-resistant.
Co nclusio n : Distribution of serotypes of S. pneuomoniae isolated from Korean children
has changed significantly over the last 15 years. The surveillance for pneumococcal serotypes
should be continued to monitor changes in serotype distribution which are essential for the
establishment of pneumococcal vaccine policy.
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