지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 210 - 215 (6page)
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초록· 키워드
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Background: Streptococcus pneumoniae causes life-threatening infections such as men- ingitis, pneumonia, and febrile bacteremia, particularly in young children. The increasing number of drug-resistant isolates has highlighted the necessity for intervening and control- ling disease. To achieve this, information is needed on serotype distribution and patterns of antibiotic resistance in children.
Methods: All cases of invasive pneumococcal disease (IPD) in children aged less than 15 yr recorded at King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia, were reviewed for serotyping and antibiotic susceptibility. Isolates were collected from 78 consecutive patients with IPD between 2009 and 2012. All collected isolates were sub- jected to serotyping by co-agglutination, sequential multiplex PCR, and single PCR se- quetyping as previously described.
Results: The most frequently isolated IPD serotypes were 23F, 6B, 19F, 18C, 4, 14, and 19A, which are listed in decreasing order and cover 77% of total isolates. The serotype coverage for the pneumococcal conjugate vaccine (PCV)7, PCV10, and PCV13 was 77%, 81%, and 90%, respectively. Results from sequential multiplex PCR agreed with co-agglu- tination results. All serotypes could not be correctly identified using single PCR sequetyp- ing. Minimum inhibitory concentration showed that 50 (64%) isolates were susceptible to penicillin, whereas 70 (90%) isolates were susceptible to cefotaxime.
Conclusions: The most common pneumococcal serotypes occur with frequencies similar to those found in countries where the PCV has been introduced. The most common sero- types in this study are included in the PCVs. Addition of 23A and 15 to the vaccine would improve the PCV performance in IPD prevention.
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참고문헌 (21)
참고문헌 신청
Al-Mazrou A / 2005 / Streptococcus pneumoniae serotypes/serogroups causing invasive disease in Riyadh, Saudi Arabia: extent of coverage by pneumococcal vaccines / Ann Saudi
Arbique JC / 2004 / Accuracy of phenotypic and genotypic testing for identification of Streptococcus pneumoniae and description of Streptococcus pseudopneumoniae sp. nov / J
Brito DA / 2003 / Serotyping Streptococcus pneumoniae by multiplex PCR / J Clin Microbiol 41 : 2378 ~ 2384
Clinical and Laboratory Standards Institute / 2009 / Performance standards for antimicrobial susceptibility testing: 29th Informational supplement / Clinical and Laboratory Standards
Dagan R / 2009 / Impact of pneumococcal conjugate vaccine on infections caused by antibiotic-resistant Streptococcus pneumoniae / Clin Microbiol Infect 15 (S3) : 16 ~ 20
Arbique JC / 2004 / Accuracy of phenotypic and genotypic testing for identification of Streptococcus pneumoniae and description of Streptococcus pseudopneumoniae sp. nov / J
Brito DA / 2003 / Serotyping Streptococcus pneumoniae by multiplex PCR / J Clin Microbiol 41 : 2378 ~ 2384
Clinical and Laboratory Standards Institute / 2009 / Performance standards for antimicrobial susceptibility testing: 29th Informational supplement / Clinical and Laboratory Standards
Dagan R / 2009 / Impact of pneumococcal conjugate vaccine on infections caused by antibiotic-resistant Streptococcus pneumoniae / Clin Microbiol Infect 15 (S3) : 16 ~ 20
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