지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Purpose: Cardiac complications may occur in cases of organophosphate (OP) poisoning. However, a few studies regarding patterns of cardiac toxicity as determined by transthoracic echocardiography (TTE) after exposure to OP have been reported. In the current study, the authors examined cardiac functions using TTE in patients with myocardial injury caused by exposure to OP.
Methods: A retrospective review was conducted on 16 consecutive cases of OP poisoning with myocardial injury (defined as elevated troponin I within 48 hours of arrival at the regional emergency center in South Korea and diagnosed and treated at the center from January 2012 to November 2014.
Results: TTE was performed in 11 (69%) of the 16 patients with an elevated troponin I (TnI) level within 48 hours.
Of these 11 patients, 5 patients (45.5%) exhibited reduced ejection fraction (EF), and 3 exhibited regional wall motion abnormality (RWMA). Two patients (18.2%) had both reduced systolic function and RWMA. Two of the 5 patients with reduced EF returned to normal systolic function, however two patients did not regain normal systolic function after admission. One patient expired due to multiple organ failure, and 4 patients were transferred with a moribund status. Twelve of 15 patients who survived to discharge (at 4 to 35 months) were followed. Five of these patients died during follow-up and 7 survived without further complications.
Conclusion: OP can cause reversible cardiac dysfunction including reduced systolic function and RWMA. Serum TnI may be useful for initial assessment of cardiac function during the workup of patients suffering from OP poisoning.
After the initial assessment of cardiac enzyme, further evaluation with TTE in patients with abnormal cardiac enzyme will be necessary to understand the cardiac toxicity.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Sungur M / 2001 / Intensive care management of organophosphate insecticide poisoning / Crit Care 5:211~215
Linden CH / 2001 / Harrison’s principles of internal medicine / McGraw-Hill :2595~2615
Roth A / 1993 / Organophosphates and the heart / Chest 103:576~582
Karki P / 2004 / Cardiac and electrocardiographical manifestations of acute organophosphate poisoning / Singapore Med J 45:385~389
Brill DM / 1984 / Polymorphic ventricular tachycardia and other complex arrhythmias in organophosphate insecticide poisoning / J Electrocardiol 17:97~102
Linden CH / 2001 / Harrison’s principles of internal medicine / McGraw-Hill :2595~2615
Roth A / 1993 / Organophosphates and the heart / Chest 103:576~582
Karki P / 2004 / Cardiac and electrocardiographical manifestations of acute organophosphate poisoning / Singapore Med J 45:385~389
Brill DM / 1984 / Polymorphic ventricular tachycardia and other complex arrhythmias in organophosphate insecticide poisoning / J Electrocardiol 17:97~102
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