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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The aim of this study was to investigate the role of osteal macrophages (osteomac) and osteocytes in bone remodeling using a mathematical model. We constructed the bone system with pre-osteoblasts, osteoclasts, osteocytes, and osteomac. Each link of the parameters and ordinary differential equations followed the Graham's model in 2013 except for the parameters of osteomac signaling and osteocytes signaling to link preosteoblasts and osteoblasts. We simulated the changes in each cell and bone volume according to the changes in the parameters of osteomac signaling and osteocytes signaling. The results showed bone volume was unstable and decreased gradually when the effectiveness of osteocytes and osteomac dropped below a certain level. When the parameters of osteomac signaling and osteocytes signaling to link preosteoblasts and osteoblasts had a value less than 1, bone volume increased with the increase in the parameter of osteomac signaling to link preosteoblasts and osteoblasts. Moreover, although the parameter of osteocytes signaling to link preosteoblasts and osteoblasts, increased in case of a small parameter of osteomac signaling, bone volulme decreased. If the parameters of osteomac signaling to link preosteoblasts and osteoblasts were over a certain level, bone volume was positively maintained, despite the parameter of osteocyte signaling to link preosteoblasts and osteoblasts. We suggested the osteomac may affect bone remodeling and may play an important role in bone cell network.
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참고문헌 (21)
참고문헌 신청
Breitling R / 2010 / What is systems biology? / Front Physiol 1:9
Kitano H / 2002 / Systems biology: a brief overview / Science 295:1662~1664
Hsu YH / 2006 / Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men / Hum Genet 118:568~577
Lamora A / 2016 / TGF-${\beta}$ signaling in bone remodeling and osteosarcoma progression / J Clin Med 5:E96
Poon B / 2016 / Bone morphogenetic protein-2 and bone therapy: successes and pitfalls / J Pharm Pharmacol 68:139~147
Kitano H / 2002 / Systems biology: a brief overview / Science 295:1662~1664
Hsu YH / 2006 / Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men / Hum Genet 118:568~577
Lamora A / 2016 / TGF-
Poon B / 2016 / Bone morphogenetic protein-2 and bone therapy: successes and pitfalls / J Pharm Pharmacol 68:139~147
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