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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 485 - 492 (8page)
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초록· 키워드
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The tumor microenvironment is comprised of diverse stromal cell populations in addition to tumor cells. Increasing evidence nowclearly supports the role of microenvironment stromal cells in tumor progression and metastasis, yet the regulatory mechanisms andinteractions among tumor and stromal cells remain to be elucidated. Bone metastasis is the major problem in many types of humanmalignancies including prostate, breast and lung cancers, and the biological basis of bone metastasis let alone curative approachesare largely undetermined. Among the many types of stromal cells in bone, osteoblasts are shown to be an important player. In this regard,osteoblasts are a key target cell type in the development of bone metastasis, but there are currently no drugs or therapeutic approachesare available that specifically target osteoblasts. This review paper summarizes the current knowledge on osteoblasts in themetastatic tumor microenvironment, aiming to provide clues and directions for future research endeavor.
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등록된 정보가 없습니다.
참고문헌 (58)
참고문헌 신청
Buenrostro D / 2014 / Dissecting the role of bone marrow stromal cells on bone metastases / Biomed Res Int 2014:875305
Soki FN / 2012 / The multifaceted actions of PTHrP in skeletal metastasis / Future Oncol 8:803~817
Park SI / 2011 / Roles of bone marrow cells in skeletal metastases: no longer bystanders / Cancer Microenviron 4:237~246
Schneider A / 2005 / Bone turnover mediates preferential localization of prostate cancer in the skeleton / Endocrinology 146:1727~1736
Zhang XH / 2013 / Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma / Cell 154:1060~1073
Soki FN / 2012 / The multifaceted actions of PTHrP in skeletal metastasis / Future Oncol 8:803~817
Park SI / 2011 / Roles of bone marrow cells in skeletal metastases: no longer bystanders / Cancer Microenviron 4:237~246
Schneider A / 2005 / Bone turnover mediates preferential localization of prostate cancer in the skeleton / Endocrinology 146:1727~1736
Zhang XH / 2013 / Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma / Cell 154:1060~1073
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