지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The purpose of this study was to examine the MAPK signaling pathways involved in regulation of HO-1 and the odontoblast differentiation markers during the odontoblastic differentiation for HDPCs. We evaluated cell growth by MTT assay and differentiation marker mRNA expression by RT-PCR. When the cells were treated with p38 inhibitor (SB203580, 10 μM), JNK inhibitor (SP600125, 10 μM), and ERK inhibitor (PD98059, 20 μM) for 7 days, cell growth and expression of HO-1 and differentiation makers were significantly decreased in HDPCs. Our results suggest that odontoblastic differentiation is positively regulated by HO-1 induction in HDPCs via ERK, JNK, and p38 signaling pathways. Thus, pharmacological HO-1 induction might represent a potent therapeutic approach for pulp capping and the regeneration of HDPCs.
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참고문헌 (23)
참고문헌 신청
Ana Cuadrado / 2007 / A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis / EMBO J 26 (8) : 2115 ~ 2126
Barbagallo I / 2008 / A cytoprotective role for the heme oxygenase-1/CO pathway during neural differentiation of human mesenchymal stem cells / J Neurosci Res 86 : 1927 ~ 19
Butler WT / 1995 / The nature and functional significance of dentin extracellular matrix proteins / Int. J. Dev. Biol 39 : 169 ~ 179
Couble ML / 2000 / Odontoblast differentiation
Durante W / 2003 / Heme oxygenase-1 in growth control and its clinical application to vascular disease / J Cell Physiol 195 (3) : 373 ~ 382
Barbagallo I / 2008 / A cytoprotective role for the heme oxygenase-1/CO pathway during neural differentiation of human mesenchymal stem cells / J Neurosci Res 86 : 1927 ~ 19
Butler WT / 1995 / The nature and functional significance of dentin extracellular matrix proteins / Int. J. Dev. Biol 39 : 169 ~ 179
Couble ML / 2000 / Odontoblast differentiation
Durante W / 2003 / Heme oxygenase-1 in growth control and its clinical application to vascular disease / J Cell Physiol 195 (3) : 373 ~ 382
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