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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충남대학교 농업과학연구소 Korean Journal of Agricultural Science Korean Journal of Agricultural Science Vol.46 No.3
- 발행연도
- 2019.9
- 수록면
- 579 - 589 (11page)
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초록· 키워드
오류제보하기
Due to the ban on the use of antibiotics, interest has been increasing for the development of therapeutic agents to treat various diseases using natural resources. Osthole, a natural coumarin compound used in traditional Chinese medicines, exerts an anti-inflammatory effect, but its effects in cows remain unknown. In this study, the effect of osthole on lipopolysaccharide (LPS)- or concanavalin-A (Con-A)- stimulated peripheral blood mononuclear cells (PBMCs) was assessed. Jugular venous blood was collected from Korean calves, and PBMCs were isolated. They were then used to study the immune response of PBMCs to treatment with osthole and LPS or Con-A for 72 h by measuring inflammatory cytokines including tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). Osthole significantly inhibited the mRNA secretion of TNF-α and IFN-γ in a dose-dependent manner. Therefore, osthole inhibited LPS- or Con-A- induced TNF-α and Con-A-induced IFN-γ production significantly in dose-dependent manner. These results clearly suggest that osthole inhibited the LPS- or Con-A- stimulated upregulation of pro-inflammatory cytokines in a dosedependent manner, without causing obvious cytotoxic effects. Osthole could also protect cows from LPS- or Con-A- induced endotoxin shock, possibly by inhibiting the production of pro-inflammatory cytokines, which suggests that osthole might be a novel therapeutic agent for the prevention of inflammatory diseases.
목차
Abstract
Introduction
Material and methods
Results
Discussion
Conclusion
References
참고문헌 (28)
참고문헌 신청
Abbas KA / 2012 / Basic immunology / Elsevier
Adams JL / 1990 / Bacterial lipopolysaccharide induces release of tumor necrosis factoralpha from bovine peripheral blood monocytes and alveolar macrophages in vitro / Journal of Leukocyte Biology 48:549~556
G R Bernard / 1994 / The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. / American Journal of Respiratory and Critical Care Medicine 149(3):818~824
Pu-Rong Chiu / 2008 / Effect of the Chinese Herb Extract Osthol on IL-4-induced Eotaxin Expression in BEAS-2B Cells / Pediatrics & Neonatology 49(4):135~140
Dinarello CA / 1996 / Cytokines as mediators in the pathogenesis of septic shock / Current Topics in Microbiology and Immunology 216:133~165
Adams JL / 1990 / Bacterial lipopolysaccharide induces release of tumor necrosis factoralpha from bovine peripheral blood monocytes and alveolar macrophages in vitro / Journal of Leukocyte Biology 48:549~556
G R Bernard / 1994 / The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. / American Journal of Respiratory and Critical Care Medicine 149(3):818~824
Pu-Rong Chiu / 2008 / Effect of the Chinese Herb Extract Osthol on IL-4-induced Eotaxin Expression in BEAS-2B Cells / Pediatrics & Neonatology 49(4):135~140
Dinarello CA / 1996 / Cytokines as mediators in the pathogenesis of septic shock / Current Topics in Microbiology and Immunology 216:133~165
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