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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.7
- 수록면
- 416 - 424 (9page)
- DOI
- 10.11002/kjfp.2019.26.4.416
이용수
초록· 키워드
오류제보하기
The physicochemical properties and immunomodulatory effects of polysaccharides isolated from the sea squirt Styela plicata were investigated. The crude polysaccharide (SP) was further fractionated into an unabsorbed fraction (SF-1) and absorbed fractions (SF-2 and SF3) to isolate polysaccharides with different molecular weights. The major constituents in the crude and fractionated polysaccharides were total carbohydrate (28.03-42.65%), uronic acid (9.88-23.76%), sulfate (18.03-29.25%), and protein (1.48-26.47%). The average molecular weights of the fractionated polysaccharides ranged from 28 to 1,187 kDa. The significant monosaccharide components of the polysaccharides were galactose (27.91-62.21%), glucose (14.79-37.63%), and glucosamine (10.74-28.31%). FT-IR analysis indicates that SP, SF-1, SF-2, and SF-3 were sulfated polysaccharides. SF-1 increased the production of nitric oxide and cytokines, such as tumor necrosis factor alpha and interleukin 6, in a dose-dependent manner in RAW 264.7 cells. Further, polymerase chain reaction analysis revealed that the mRNA expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) was markedly increased. These results indicate that SF-1 can enhance the activation of macrophages and that increasing the molecular weight and the uronic acid and sulfate content of fractionated polysaccharides can enhance their immunomodulatory function.
목차
Abstract
Introduction
Materials and methods
Results and discussion
References
참고문헌 (38)
참고문헌 신청
Hooper LV / 2012 / Interactions between the microbiota and the immune system / Science 336:1268~1273
Klimp AH / 2002 / A potential role of macrophage activation in the treatment of cancer / Crit Rev Oncol Hematol 44:143~161
Commins SP / 2010 / Immunologic messenger molecules: cytokines, interferons, and chemokines / J Allergy Clin Immunol 125:53~72
Medzhitov R / 2000 / Innate immune recognition : mechanisms and pathways / Immunol Rev 173:89~97
Lee JS / 2013 / Purification, characterization and immunomodulating activity of a pectic polysaccharide isolated from Korean mulberry fruit Oddi (Morus alba L.) / Int Immunopharmacol 17:858~866
Klimp AH / 2002 / A potential role of macrophage activation in the treatment of cancer / Crit Rev Oncol Hematol 44:143~161
Commins SP / 2010 / Immunologic messenger molecules: cytokines, interferons, and chemokines / J Allergy Clin Immunol 125:53~72
Medzhitov R / 2000 / Innate immune recognition : mechanisms and pathways / Immunol Rev 173:89~97
Lee JS / 2013 / Purification, characterization and immunomodulating activity of a pectic polysaccharide isolated from Korean mulberry fruit Oddi (Morus alba L.) / Int Immunopharmacol 17:858~866
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UCI(KEPA) : I410-ECN-0101-2019-059-000954201