지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.6
- 수록면
- 173 - 185 (13page)
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초록· 키워드
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Background: Galgeun-tang used in traditional Korean medicine, is a mixture of the medicinal plants Cinnamomi Ramulus, Ephedrae Herba and Puerariae Radix, and has been prescribed for the treatment of various ailments, including fever. Although the use of traditional medicinal herbs to treat diseases has recently increased, their safety and toxicity profiles incompletely elucidated. Thus, we evaluated Galgeun-tang’s toxicity in male and female Sprague-Dawley rats.
Methods and Results: Galgeun-tang (1,000, 2,000 and 4,000 ㎎/㎏) was orally administered to rats for 13 weeks, and then, they were maintained for 4 weeks without administration (recovery period). Their clinical signs, and hematological and urinary properties, were monitored. The results showed that Galgeun-tang administeration slightly increased serum creatinine, urea nitrogen and, aspartate aminotransferase levels. Additionally, 2,000 and 4,000 ㎎/㎏ Galgeun-tang significantly increased urinary bilirubn and protein levels of male and female rats, which were restored during the recovery period.
Conclusions: The no-observed-adverse-effect level of orally administered Galgeun-tang was 4,000 ㎎/㎏ in both female and male rats, and no target organs were identified. In addition, 400 ㎎/㎏ was found to be the no-observed-effect level for toxicity under the study conditions.
Methods and Results: Galgeun-tang (1,000, 2,000 and 4,000 ㎎/㎏) was orally administered to rats for 13 weeks, and then, they were maintained for 4 weeks without administration (recovery period). Their clinical signs, and hematological and urinary properties, were monitored. The results showed that Galgeun-tang administeration slightly increased serum creatinine, urea nitrogen and, aspartate aminotransferase levels. Additionally, 2,000 and 4,000 ㎎/㎏ Galgeun-tang significantly increased urinary bilirubn and protein levels of male and female rats, which were restored during the recovery period.
Conclusions: The no-observed-adverse-effect level of orally administered Galgeun-tang was 4,000 ㎎/㎏ in both female and male rats, and no target organs were identified. In addition, 400 ㎎/㎏ was found to be the no-observed-effect level for toxicity under the study conditions.
목차
ABSTRACT
서언
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (19)
참고문헌 신청
Amacher DE / 1998 / The relationship among microsomal enzyme induction, liver weight and histological change in rat toxicology studies / Food and Chemical Toxicology 36:831~819
Bickers D / 2005 / A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients: The RIFM expert panel / Food and Chemical Toxicology 43:799~836
Chung HJ / 2009 / Toxicological evaluation of the isoflavone puerarin and its glycosides / European Food Research and Technology 230:145~153
Dietze S / 2016 / Food deprivation, body weight loss and anxiety-related behavior in rats / Animals 6:E4
하혜경 / 2013 / Galgeun-tang, an Herbal Formula, Ameliorates Atopic Dermatitis Responses in Dust Mite Extract-treated NC/Nga Mice / 대한한의학회지 34(4):1~11
Bickers D / 2005 / A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients: The RIFM expert panel / Food and Chemical Toxicology 43:799~836
Chung HJ / 2009 / Toxicological evaluation of the isoflavone puerarin and its glycosides / European Food Research and Technology 230:145~153
Dietze S / 2016 / Food deprivation, body weight loss and anxiety-related behavior in rats / Animals 6:E4
하혜경 / 2013 / Galgeun-tang, an Herbal Formula, Ameliorates Atopic Dermatitis Responses in Dust Mite Extract-treated NC/Nga Mice / 대한한의학회지 34(4):1~11
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UCI(KEPA) : I410-ECN-0101-2019-480-000930993