지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Due to the major role played by several species of Streptococcus in the etiology of periodontitis, it is important to assess the pattern of Streptococcus pathogenic pathways within the infected subgingival pockets using a bacterial specific 16S rRNA fragment. From the total of 50 patients with periodontitis included in the study, only 23 Streptococcal isolates were considered for further analyses, in which their 16S rRNA fragments were amplified and sequenced. Then, a comprehensive phylogenetic tree was constructed and in silico prediction was performed for the observed Streptococcal species. The phylogenetic analysis of the subgingival Streptococcal species revealed a high discrimination power of the 16S rRNA fragment to accurately identify three groups of Streptococcus on the species level, including S. salivarius (14 isolates), S. anginosus (5 isolates), and S. gordonii (4 isolates). The employment of state-of-art in silico tools indicated that each Streptococcal species group was characterized with particular transcription factors that bound exclusively with a different 16S rRNA-based secondary structure. In conclusion, the observed data of the present study provided in-depth insights into the mechanism of each Streptococcal species in its pathogenesis, which differ in each observed group, according to the differences in the 16S rRNA secondary structure it takes, and the consequent binding with its corresponding transcription factors. This study paves the way for further interventions of the in silico prediction, with the main conventional in vitro microbiota identification to present an interesting insight in terms of the gene expression pattern and the signaling pathway that each pathogenic species follows in the infected subgingival site.
목차
Material and Methods
Results
Discussion
Conclusion
References
참고문헌 (36)
참고문헌 신청
Abranches J, Zeng L, Kajfasz JK, Palmer SR, Chakraborty B, Wen ZT, Richards VP, Brady LJ, and Lemos JA. 2018. Biology of oral streptococci. Microbiol. Spectr. 6, 10.1128/microbiolspec.GPP3- 0042-2018.
Al-Jehani YA. 2014. Risk factors of periodontal disease: review of the literature. Int. J. Dent. 2014, 182513.
Al-Shuhaib MBS, Albakri AH, Alwan SL, Almandil NB, AbdulAzeez S, and Borgio JF. 2018. Optimal PCR primers for rapid and accurate detection of Aspergillus flavus isolates. Microb. Pathog. 116, 351?355.
Bachhawat P, Swapna GV, Montelione GT, and Stock AM. 2005. Mechanism of activation for transcription factor PhoB suggested by different modes of dimerization in the inactive and active states. Structure 13, 1353?1363.
Bansal T, Pandey ADD, and Asthana AK. 2014. C-Reactive protein (CRP) and its association with periodontal disease: a brief review. J. Clin. Diagn. Res. 8, ZE21-4.
Al-Jehani YA. 2014. Risk factors of periodontal disease: review of the literature. Int. J. Dent. 2014, 182513.
Al-Shuhaib MBS, Albakri AH, Alwan SL, Almandil NB, AbdulAzeez S, and Borgio JF. 2018. Optimal PCR primers for rapid and accurate detection of Aspergillus flavus isolates. Microb. Pathog. 116, 351?355.
Bachhawat P, Swapna GV, Montelione GT, and Stock AM. 2005. Mechanism of activation for transcription factor PhoB suggested by different modes of dimerization in the inactive and active states. Structure 13, 1353?1363.
Bansal T, Pandey ADD, and Asthana AK. 2014. C-Reactive protein (CRP) and its association with periodontal disease: a brief review. J. Clin. Diagn. Res. 8, ZE21-4.
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