Propionate Attenuates Growth of Oral Streptococci through Enhancing Methionine Biosynthesis

Park Taehwan; Im Jintaek; Kim A Reum; Lee Dongwook; Jeong Sungho; Yun Cheol-Heui; 한승현

doi:10.4014/jmb.2205.05037

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자료유형: 학술저널

저자정보: Park Taehwan (Department of Oral Microbiology and Immunology and Dental Research Institute School of Dentistry Se) Im Jintaek (Department of Oral Microbiology and Immunology and Dental Research Institute School of Dentistry Se) Kim A Reum (Department of Oral Microbiology and Immunology and Dental Research Institute School of Dentistry Se) Lee Dongwook (Department of Oral Microbiology and Immunology and Dental Research Institute School of Dentistry Se) Jeong Sungho (Department of Oral Microbiology and Immunology and Dental Research Institute School of Dentistry Se) Yun Cheol-Heui (Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences Se) 한승현 (서울대학교)

저널정보: 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제32권 제10호

발행연도: 2022.10

수록면: 1,234 - 1,244 (11page)

DOI: 10.4014/jmb.2205.05037

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Oral streptococci are considered as an opportunistic pathogen associated with initiation and progression of various oral diseases. However, since the currently-available treatments often accompany adverse effects, alternative strategy is demanded to control streptococci. In the current study, we investigated whether short-chain fatty acids (SCFAs), including sodium acetate (NaA), sodium propionate (NaP), and sodium butyrate (NaB), can inhibit the growth of oral streptococci. Among the tested SCFAs, NaP most potently inhibited the growth of laboratory and clinically isolated strains of Streptococcus gordonii under anaerobic culture conditions. However, the growth inhibitory effect of NaP on six different species of other oral streptococci was different depending on their culture conditions. Metabolic changes such as alteration of methionine biosynthesis can affect bacterial growth. Indeed, NaP enhanced intracellular methionine levels of oral streptococci as well as the mRNA expression level of methionine biosynthesis-related genes. Collectively, these results suggest that NaP has an inhibitory effect on the growth of oral streptococci, which might be due to alteration of methionine biosynthesis. Thus, NaP can be used an effective bacteriostatic agent for the prevention of oral infectious diseases caused by oral streptococci.

#Short-chain fatty acids #propionate #oral streptococci #bacterial growth #methionine

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