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논문 기본 정보

자료유형
학술저널
저자정보
Jung Dae Lee (Sungkyunkwan University) Joo Young Lee (The Catholic University of Korea) Seung Jun Kwack (Changwon National University) Chan Young Shin (Konkuk University) Hyun-Jun Jang (Dankook University) Hyang Yeon Kim (Dankook University) Min Kook Kim (Sungkyunkwan University) Dong-Wan Seo (Dankook University) Byung-Mu Lee (Sungkyunkwan University) Kyu-Bong Kim (Dankook University)
저널정보
한국독성학회 Toxicological Research Toxicological Research Vol.35 No.2
발행연도
2019.4
수록면
137 - 154 (18page)

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Triclosan (TCS) is an antimicrobial compound used in consumer products. The purpose of current study was to examine toxicology and risk assessment of TCS based on available data. Acute toxicities of oral, transdermal and inhalation routes were low, and phototoxicity and neurotoxicity were not observed. Topical treatment of TCS to animal caused mild irritation. TCS did not induce reproductive and developmental toxicity in rodents. In addition, genotoxicity was not considered based on in vitro and in vivo tests of TCS. It is not classified as a carcinogen in international authorities such as International Agency for Research on Cancer (IARC). No-observed-adverseeffect level (NOAEL) was determined 12 ㎎/㎏ bw/day for TCS, based on haematoxicity and reduction of absolute and relative spleen weights in a 104-week oral toxicity study in rats. Percutaneous absorption rate was set as 14%, which was human skin absorption study reported by National Industrial Chemicals Notification and Assessment Scheme (NICNAS) (2009). The systemic exposure dosage (SED) of TCS has been derived by two scenarios depending on the cosmetics usage of Koreans. The first scenario is the combined use of representative cosmetics and oral care products. The second scenario is the combined use of rinse-off products of cleansing, deodorants, coloring products, and oral care products. SEDs have been calculated as 0.14337 ㎎/㎏ bw/day for the first scenario and 0.04733 ㎎/㎏ bw/day for the second scenario. As a result, margin of safety (MOS) for the first and second scenarios was estimated to 84 and 253.5, respectively. Based on these results, exposure of TCS contained in rinse-off products, deodorants, and coloring products would not pose a significant health risk when it is used up to 0.3%.
#Triclosan #Cosmetic ingredients #Risk assessment #Rinse-off products

목차

Abstract
INTRODUCTION
HAZARD IDENTIFICATION
DOSE-RESPONSE ASSESSMENT
EXPOSURE ASSESSMENT
RISK CHARACTERIZATION
SUMMARY AND CONCLUSION
REFERENCES

참고문헌 (68)

참고문헌 신청
Litton Bionetics Inc / 1983 / 90-Day Oral Toxicity Study in Rats with Fat 80-023/H (Litton Bionetics Inc.) Final Report google schola National Industrial Chemicals Notification And Assessment Scheme / Priority Existing Chemical Assessment Report No. 30. Triclosan google schola Schmid, H. / 1994 / 13-Week Toxicity Study with Fat 80'023/R in the Hamster, Final Report google schola Leuschner, F. / 1970 / 90 Days Oral Toxicity Study in Beagle Dogs with CH 3565 google schola Paterson, R.A. / 1969 / 13-Week Oral Toxicity Study in Rabbits / Irgasan DP 300, GP 41 353, Ciba-Geigy UK google schola

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