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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.3
- 수록면
- 107 - 112 (6page)
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The corpus luteum (CL) is composed to various cells, such as luteal steroidogenic cells (LSCs), luteal thecal steroidogenic cells (LTCs), luteal endothelial cells (LECs), fibroblast, immune cells and blood cells. The life span of CL is controlled by proliferation and apoptosis of luteal cells. Therefore, this study investigated apoptotic factors in luteal cells derived from bovine CL. The CL tissues were collected from bovine ovaries and luteal cells were isolated from middle phase CL. Then, LTCs and LECs were separated according to cellular morphology from LSCs. The expression of Bax, Bcl-2, Fas and tumor necrosis factor 1 receptor (TNF1R) mRNA and protein were analyzed using quantitative RT-PCR and western blot. Results show that, Bax and TNFR1 mRNA expression were significantly increased at late group than early and middle groups, otherwise Bcl-2 were significantly decreased at late group than early group (P<0.05). Fas mRNA expression were significantly decreased in middle group compared to early and late groups (P<0.05). In addition, Bax and Bcl-2 mRNA in LTCs was lower than LSCs, Fas mRNA was higher than LSCs. The Bcl-2 protein expression was lower at LTCs than LSCs, especially Fas protein in LTCs was significantly lower than LSCs and LECs (P<0.05). Otherwise, TNFR1 protein of LTCs were similar with LSCs but higher compared with LECs. In conclusion, we suggest that the results may help understanding of apoptosis ability in luteal cells according to cell type during CL regression of estrous cycle.
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참고문헌 (26)
참고문헌 신청
Abulafia O / 2000 / Angiogenesis of the ovary / American Journal of Obstetrics and Gynecology 182:240~246
Benyo DF / 1992 / Tumor necrosis factor-alpha alters bovine luteal cell synthetic capacity and viability / Endocrinology 130:854~860
Berisha B / 2016 / Angiogenesis in the ovary–the most important regulatory event for follicle and corpus luteum development and function in cow–an overview / Anatomia, Histologia, Embryologia 45:124~130
Chouhan V / 2014 / Stimulatory effect of vascular endothelial growth factor on progesterone production and survivability of cultured bubaline luteal cells / Animal Reproduction Science 148:251~259
Davis JS / 2002 / The corpus luteum: An ovarian structure with maternal instincts and suicidal tendencies / Frontiers in Bioscience 7:d1949~d1978
Benyo DF / 1992 / Tumor necrosis factor-alpha alters bovine luteal cell synthetic capacity and viability / Endocrinology 130:854~860
Berisha B / 2016 / Angiogenesis in the ovary–the most important regulatory event for follicle and corpus luteum development and function in cow–an overview / Anatomia, Histologia, Embryologia 45:124~130
Chouhan V / 2014 / Stimulatory effect of vascular endothelial growth factor on progesterone production and survivability of cultured bubaline luteal cells / Animal Reproduction Science 148:251~259
Davis JS / 2002 / The corpus luteum: An ovarian structure with maternal instincts and suicidal tendencies / Frontiers in Bioscience 7:d1949~d1978
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UCI(KEPA) : I410-ECN-0101-2019-510-000546376