지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.24 No.1
- 발행연도
- 2019.3
- 수록면
- 32 - 40 (9page)
- DOI
- 10.3746/pnf.2019.24.1.32
이용수
초록· 키워드
오류제보하기
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, however the exact cause of NAFLD remains unknown. Methionine, an essential amino acid, is the first limiting amino acid of soy protein, and its deficiency is suggested to cause hepatocyte damage and NAFLD. The objective of this study is to examine the changes in NAFLD susceptibility with soy protein consumption and deterioration due to prohibitin 1 (PHB1) deficiency, an important protein in hepatic mitochondrial function. In this study, liver-specific phb1 ＋/− mice and wild-type mice were fed a normal diet, choline-deficient diet (CDD), or soy protein diet without choline (SPD) for 16 weeks. Using hematoxylin and eosin staining, we showed that SPD attenuates symptoms of hepatocyte damage and lipid accumulation induced by CDD in mouse liver. The liver damage in mice fed the SPD was alleviated by decreasing lipogenic markers and by increasing anti-inflammatory markers. Furthermore, mRNA expression of genes involved in hepatic methionine metabolism was significantly lower in liver-specific phb1 ＋/− mice fed with a SPD compared with wild-type mice fed with a SPD. These data suggest a CDD can cause non-alcohol related liver damage, which can be attenuated by a SPD in wild-type mice. These phenomena were not observed in liver-specific phb1 ＋/− mice. It may therefore be concluded that SPD attenuates CDDinduced liver damage in wild-type mice, and that PHB1 deficiency blocks the beneficial effects of SPD against CDD-induced liver damage.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Development for early diagnosis of liver disease using metabolite changes in liver-specific Phb1 deficient mice
한국식품영양과학회 학술대회발표집
2021 .10
-
Research on the development of biomarkers for liver disease susceptibility diagnosis using omics analysis in liver specific prohibitin 1 deficient mice
한국식품영양과학회 학술대회발표집
2023 .10
-
Changes of nutritional science research method paradigm from CLASSIC to DATA: Example of biomarker-searching for the diagnosis of liver disease susceptibility by omics analysis in liver specific prohibitin 1 deficient mice
한국식품영양과학회 학술대회발표집
2023 .10
-
Functionality study of fucoidan in the improvement of fatty liver in NAFLD-induced liver cells
한국식품영양과학회 학술대회발표집
2023 .10
-
Adjuvant-active seaweed Codium polysaccharide increases immune responds to Gardasil® in mice
한국식품영양과학회 학술대회발표집
2016 .10
-
Lactobacillus paragasseri supplements attenuate liver inflammation by improving insulin resistance and fatty liver disease in high-fat diet-induced obese mice
한국식품영양과학회 학술대회발표집
2024 .10
-
Ameliorative Effects of Pomegranate Peel Extract against Dietary-Induced Nonalcoholic Fatty Liver in Rats
Preventive Nutrition and Food Science
2016 .03
-
Bombyx mori (Silkworm) Improves Non-Alcoholic Fatty Liver Disease in High Fat Diet-Fed Mice
한국식품영양과학회 학술대회발표집
2020 .10
-
Purification and Characterization of Antioxidative Peptides from Krill Protein Hydrolysates that Protects Liver against Ethanol-induced Liver Damage in BALB/c Mice
한국식품영양과학회 학술대회발표집
2015 .08
-
Co-supplementation of coenzyme Q and selenium ameliorates the hepatic ferroptosis and the development of non-alcoholic fatty liver disease (NAFLD) in mice
한국식품영양과학회 학술대회발표집
2022 .10
-
Ameliorative Effect of Fermented Chestnut Inner Skin Extract on Non-Alcoholic Fatty Liver in High Fat Diet-Fed Mice
한국식품영양과학회 학술대회발표집
2015 .08
-
The Effect of Isoliquiritigenin Supplementation on Fatty Liver in Diet-Induced Obese Mice
한국식품영양과학회 학술대회발표집
2018 .10
-
Effects of Sea rice waste extract on blood glucose level and fatty liver in Type 2 diabetes Mice
한국식품영양과학회 학술대회발표집
2024 .10
-
Polymerized Anthocyanin from Grape Skin Extract Alleviates High-fat Diet-induced Non-alcoholic Fatty Liver in Experimental Mice
한국식품영양과학회 학술대회발표집
2019 .10
-
Organoid Establishment of Long-Term Culture Using Primary Mouse Hepatocytes and Evaluation of Liver Function
Preventive Nutrition and Food Science
2023 .09
-
Protective Effect of Carvacrol on Acute Alcohol-Induced Liver Disease Model in Mice
한국식품영양과학회 학술대회발표집
2018 .10
-
Arazyme Ameliorates Hepatic Steatosis and Insulin Resistance in Diet-induced Non-alcoholic Fatty Liver Disease Mouse Model
한국식품영양과학회 학술대회발표집
2016 .10
-
Organoid Establishment for Long-Term Culture using Primary Mouse Hepatocytes and Evaluation of Liver Function as a Health Functional Food Test Model
한국식품영양과학회 학술대회발표집
2022 .10
-
Cheonggukjang Prevents Hyperlipidemia Ameliorates the Progression of Nonalcoholic Fatty Liver Disease in Mice Fed a High-Fat/Cholesterol Diet
한국식품영양과학회 학술대회발표집
2024 .10
-
Protective Effect of Curcuma longa L. on Alcoholic Fatty Liver in C57BL/6 Mice
한국식품영양과학회 학술대회발표집
2018 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2019-594-000543291