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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제4호
- 발행연도
- 2021.1
- 수록면
- 321 - 331 (11page)
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초록· 키워드
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Vancomycin, an antibiotic used occasionally as a last line of treatment for methicillin-resistant Staphylococcus aureus, is reportedly associated with nephrotoxicity. This study aimed at evaluating the protective effects of lutein against vancomycin- induced acute renal injury. Peroxisome proliferator-activated receptor gamma (PPAR?) and its associated role in renoprotection by lutein was also examined. Male BALB/c mice were divided into six treatment groups: control with normal saline, lutein (200 mg/kg), vancomycin (250 mg/kg), vancomycin (500 mg/kg), vancomycin (250 mg/kg) with lutein, and vancomycin (500 mg/kg) with lutein groups; they were euthanized after 7 days of treatment. Thereafter, samples of blood, urine, and kidney tissue of the mice were analyzed, followed by the determination of levels of N-acetyl- ?-D-glucosaminidase (NAG) in the urine, renal creatine kinase; protein carbonyl, malondialdehyde, and caspase-3 in the kidney; and the expression of PPAR?, nuclear factor erythroid 2-related factor 2 (Nrf2), and nuclear factor-kappaB (NF-?B) in renal tissue. Results showed that the levels of protein carbonyl and malondialdehyde, and the activity of NAG, creatine kinase and caspase-3, were significantly increased in the vancomycin-treatment groups. Moreover, the levels of Nrf2 significantly decreased, while NF-?B expression increased. Lutein ameliorated these effects, and significantly increased PPAR? expression. Furthermore, it attenuated vancomycin-induced histological alterations such as, tissue necrosis and hypertrophy. Therefore, we conclude that lutein protects against vancomycin-induced renal injury by potentially upregulating PPAR?/Nrf2 expression in the renal tissues, and consequently downregulating the pathways: inflammation by NF-?B and apoptosis by caspase-3.
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참고문헌 (56)
참고문헌 신청
Jorgensen SCJ / 2020 / A multicenter evaluation of vancomycin-associated acute kidney injury in hospitalized patients with acute bacterial skin and skin structure infections / Infect Dis Ther 9:89~106
Dieterich C / 2009 / Gene expression analysis reveals new possible mechanisms of vancomycin-induced nephrotoxicity and identifies gene markers candidates / Toxicol Sci 107:258~269
Lodise TP / 2008 / Larger vancomycin doses(at least four grams per day)are associated with an increased incidence of nephrotoxicity / Antimicrob Agents Chemother 52:1330~1336
Rybak M / 2009 / Therapeutic monitoring of vancomycin in adult patients : a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists / Am J Health Syst Pharm 66:82~98
Qin X / 2020 / Vancomycin-associated acute kidney injury in Hong Kong in 2012-2016 / BMC Nephrol 21:41
Dieterich C / 2009 / Gene expression analysis reveals new possible mechanisms of vancomycin-induced nephrotoxicity and identifies gene markers candidates / Toxicol Sci 107:258~269
Lodise TP / 2008 / Larger vancomycin doses(at least four grams per day)are associated with an increased incidence of nephrotoxicity / Antimicrob Agents Chemother 52:1330~1336
Rybak M / 2009 / Therapeutic monitoring of vancomycin in adult patients : a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists / Am J Health Syst Pharm 66:82~98
Qin X / 2020 / Vancomycin-associated acute kidney injury in Hong Kong in 2012-2016 / BMC Nephrol 21:41
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