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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.9
- 수록면
- 238 - 243 (6page)
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Tuberculosis is a global public health problem and manifests itself as a difference in the genetic susceptibility of the host, along with the properties of Mycobacterium tuberculosis (MTB). The single nucleotide polymorphisms (SNPs) and candidate genes proposed in the Genome-wide association study (GWAS) on tuberculosis in a recently published Chinese population were reported. In this study, we investigated whether the genetic polymorphism of candidate genes related to tuberculosis is reproduced when targeting Koreans. The CLCN6 (rs12404124, rs198391, rs535107), DOK7 (rs1203104, rs1203103) and HLA-DRA (rs1051336) gene polymorphisms showed statistically significant results. In addition, it was also found whether it acts as an expression quantitative trait loci (eQTL) that can influence gene expression. This study confirmed that the genetic polymorphism of the three genes (CLCN6, DOK7, HLA-DRA) affects the development of tuberculosis and will help to understand the genetic specificity of tuberculosis and the interaction between pathogens and hosts.
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참고문헌 (19)
참고문헌 신청
Bergamin E / 2010 / The cytoplasmic adaptor protein DOK7 activates the receptor tyrosine kinase MuSK via dimerization / Molecular Cell 39:100~109
Bhattacharyya C / 2019 / An exome wide association study of pulmonary tuberculosis patients and their asymptomatic household contacts / Infection, Genetics and Evolution 71:76~81
Bissay V / 2019 / Phenotypic differences in 2 unrelated cases carrying Identical DOK7 mutations / Journal of Clinical Neuromuscular Disease 21:30~34
조경숙 / 2018 / Tuberculosis control in the Republic of Korea / Epidemiology and Health 40:1~6
Cho YS / 2009 / A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nat Genet 41:527~534
Bhattacharyya C / 2019 / An exome wide association study of pulmonary tuberculosis patients and their asymptomatic household contacts / Infection, Genetics and Evolution 71:76~81
Bissay V / 2019 / Phenotypic differences in 2 unrelated cases carrying Identical DOK7 mutations / Journal of Clinical Neuromuscular Disease 21:30~34
조경숙 / 2018 / Tuberculosis control in the Republic of Korea / Epidemiology and Health 40:1~6
Cho YS / 2009 / A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nat Genet 41:527~534
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UCI(KEPA) : I410-ECN-0101-2020-510-001305943