지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 455 - 461 (7page)
이용수
초록· 키워드
오류제보하기
Obesity, a strong risk factor for the development of chronic diseases, is characterized by an increase in the number and size of adipocytes differentiated from precursor cells, preadipocytes. Recent research suggests that increased reactive oxygen species (ROS) production in 3T3-L1 adipocyte facilitates adipocyte differentiation and fat accumulation. This study was to investigate whether reduced ROS production by Sargassum micracanthum extract (SME) could protect the development of obesity through inhibition of adipogenesis. 3T3-L1 preadipocytes were treated SME for up to 8 days following standard induction of differentiation. The extent of differentiation reflected by amount of lipid accumulation and ROS production was determined by Oil red O staining and nitroblue tetrazolium (NBT) assay. Treatment of SME significantly inhibited ROS production and adipocyte differentiation that is depend on down regulation of NADPH oxidase 4 (NOX4), a major ROS generator, and peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding protein alpha (C/EBPα), a key adipogenic transcription factor. These results indicate that SME can inhibit adipogenesis through a reduced ROS level that involves down-regulation of NOX4 expression or via modulation of adipogenic transcription factor.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Spiegelman BM / 2001 / Obesity and the regulation of energy balance / Cell 104:531~543
Marcelin G / 2010 / Contributions of adipocyte lipid metabolism to body fat content and implications for the treatment of obesity / Curr Opin Pharmacol 10:588~593
Holst D / 2002 / New factors in the regulation of adipose differentiation and metabolism / Curr Opin Lipidol 13:241~245
de Ferranti S / 2008 / The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences / Clin Chem 54:945~955
Attie AD / 2009 / Adipocyte metabolism and obesity / J Lipid Res 50:395~359
Marcelin G / 2010 / Contributions of adipocyte lipid metabolism to body fat content and implications for the treatment of obesity / Curr Opin Pharmacol 10:588~593
Holst D / 2002 / New factors in the regulation of adipose differentiation and metabolism / Curr Opin Lipidol 13:241~245
de Ferranti S / 2008 / The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences / Clin Chem 54:945~955
Attie AD / 2009 / Adipocyte metabolism and obesity / J Lipid Res 50:395~359
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-059-003066022