지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.94 No.4
- 발행연도
- 2018.4
- 수록면
- 174 - 182 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Radiation proctitis (RP) is inflammation and damage to the rectum, manifested secondary to ionizing radiation utilized for treatment. In this study, we evaluated the anti-inflammatory therapeutical and protective effects of ruscogenin in a model of acute RP.
Methods: Thirty-two Sprague-Dawley rats were divided into 4 groups (n = 8) as sham, control, treatment, and prophylaxis groups. Prophylaxis group and treatment group were dosed ruscogenin by oral gavage for 14 days pre- and postradiation. At the end of the 28th day, all subjects were sacrificed.
Results: Histopathological analysis showed a significant increase in cryptitis abscess, cryptitis and reactive atypia, and depth of lymphocytic infiltration of the control group, compared to the other groups (P < 0.05), while treatment and prophylaxis groups showed significant decreases (P < 0.05). Immunohistochemical analysis indicated that immunoreactivity were significantly higher in control group (P < 0.05, P < 0.001, and P < 0.01, respectively), but vice versa for treatment and prophylaxis groups. There was not any significant difference for fibroblast growth factor 2 immunoreactivity. The epithelium of control rectums indicated an increase in TNF-α immunoreactivity while other groups had significant decrease (P < 0.01). Electron microscopical findings were parallel to light microscopy.
Conclusion: In this study, ruscogenin was observed to be effective on prophylaxis or treatment of acute RP. Although there are various reports on the treatment of the rectum damaged by acute RP in the literature, this could be the first study since there is no research indicating the ultrastructural effect of ruscogenin.
Methods: Thirty-two Sprague-Dawley rats were divided into 4 groups (n = 8) as sham, control, treatment, and prophylaxis groups. Prophylaxis group and treatment group were dosed ruscogenin by oral gavage for 14 days pre- and postradiation. At the end of the 28th day, all subjects were sacrificed.
Results: Histopathological analysis showed a significant increase in cryptitis abscess, cryptitis and reactive atypia, and depth of lymphocytic infiltration of the control group, compared to the other groups (P < 0.05), while treatment and prophylaxis groups showed significant decreases (P < 0.05). Immunohistochemical analysis indicated that immunoreactivity were significantly higher in control group (P < 0.05, P < 0.001, and P < 0.01, respectively), but vice versa for treatment and prophylaxis groups. There was not any significant difference for fibroblast growth factor 2 immunoreactivity. The epithelium of control rectums indicated an increase in TNF-α immunoreactivity while other groups had significant decrease (P < 0.01). Electron microscopical findings were parallel to light microscopy.
Conclusion: In this study, ruscogenin was observed to be effective on prophylaxis or treatment of acute RP. Although there are various reports on the treatment of the rectum damaged by acute RP in the literature, this could be the first study since there is no research indicating the ultrastructural effect of ruscogenin.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Examination of protective and therapeutic effects of ruscogenin on cerulein-induced experimental acute pancreatitis in rats
Annals of Surgical Treatment and Research
2019 .12
-
Clinical utilization of long-acting granulocyte colony-stimulating factor (pegfilgrastim) prophylaxis in breast cancer patients with adjuvant docetaxel-cyclophosphamide chemotherapy
Annals of Surgical Treatment and Research
2021 .02
-
Appropriate Use of Surgical Antibiotic Prophylaxis
Journal of Korean Medical Science
2019 .01
-
A Study of Halitosis Concentration Variations before and after Oral Prophylaxis Using the BB Checker
International Journal of Clinical Preventive Dentistry
2020 .01
-
레이노 현상의 진단적 접근
대한내과학회지
2019 .10
-
Radiation Proctitis and Management Strategies
Clinical Endoscopy
2022 .01
-
Raynaud’s Phenomenon: A Current Update on Pathogenesis, Diagnostic Workup, and Treatment
Vascular Specialist International
2024 .09
-
A Comparison of ABOi LT and HLA-DSA (+) LT
대한외과학회 학술대회 초록집
2019 .10
-
Clinical data on treatment regimen and use of medication among patients with hemophilia B in Korea
Blood Research
2024 .09
-
Interstitial Lung Change in Pre-radiation Therapy Computed Tomography Is a Risk Factor for Severe Radiation Pneumonitis
Cancer Research and Treatment
2015 .01
-
Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells
Journal of Ginseng Research
2020 .11
-
“Targeted” prophylaxis: Impact of rectal swab culture-directed prophylaxis on infectious complications after transrectal ultrasound-guided prostate biopsy
Investigative and Clinical Urology
2017 .01
-
RPS15a Silencing Suppresses Cell Proliferation and Migration of Gastric Cancer
Yonsei Medical Journal
2018 .01
-
The inhibitory activity of ginsenoside Rp4 in adenosine diphosphate-induced platelet aggregation
Journal of Ginseng Research
2017 .01
-
레이노현상에서 손톱주름 모세혈관경의 유용성
대한류마티스학회지
2015 .01
-
Infections in Lung Transplant Recipients during and after Prophylaxis
Infection and Chemotherapy
2020 .01
-
Comparison of the short-term outcomes of reduced-port laparoscopic surgery and conventional multiport surgery in colon cancer : a propensity score matching analysis
Annals of Surgical Treatment and Research
2018 .03
-
Acute and sub-acute oral toxicity study of multi-mineral compound in rats
한국실험동물학회 학술발표대회 논문집
2019 .07
-
치과용 쾌속조형기(RP)의 정확도 평가
대한치과재료학회 학술대회
2016 .04
-
A survey evaluating hematology physicians' perspectives on central nervous system prophylaxis
Blood Research
2023 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-514-001913151